The Need for Drugs and Drug Delivery Systems

Wilson, Clive G.

doi:10.1007/978-1-4614-0881-9_1

Cited by 3 publications

(4 citation statements)

References 2 publications

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“…Organic nanocarriers are generally characterized by their tunable morphology, colloidal stability, relatively large size, high biocompatibility and improved drug loading capacity, which make them suitable for transporting a wide variety of drugs [ 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. However, it is very important to make sure that the polymeric drug nanocarriers are safe and do not trigger cytotoxicity at the tissue level.…”

Section: Polymer-based Smart Nanocarriersmentioning

confidence: 99%

Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters

Nikkhah

Thompson

2021

Pharmaceutics

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Nanomedicine employs molecular materials for prevention and treatment of disease. Recently, smart nanoparticle (NP)-based drug delivery systems were developed for the advanced transport of drug molecules. Rationally engineered organic and inorganic NP platforms hold the promise of improving drug targeting, solubility, prolonged circulation, and tissue penetration. However, despite great progress in the synthesis of NP building blocks, more interdisciplinary research is needed to understand their self-assembly and optimize their performance as smart nanocarriers. Multi-scale modeling and simulations provide a valuable ally to experiment by mapping the potential energy landscape of self-assembly, translocation, and delivery of smart drug-loaded NPs. Here, we highlight key recent advances to illustrate the concepts, methods, and applications of smart polymer-based NP drug delivery. We summarize the key design principles emerging for advanced multifunctional polymer topologies, illustrating how the unusual architecture and chemistry of dendritic polymers, self-assembling polyelectrolytes and cyclic polymers can provide exceptional drug delivery platforms. We provide a roadmap outlining the opportunities and challenges for the effective use of predictive multiscale molecular modeling techniques to accelerate the development of smart polymer-based drug delivery systems.

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Section: Polymer-based Smart Nanocarriersmentioning

confidence: 99%

Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters

Nikkhah

Thompson

2021

Pharmaceutics

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“…Drug delivery systems hold an active agent concentration in plasma between the minimum effective concentration and the minimum toxic concentration to achieve the therapeutic effect (Perrie and Rades, 2012;Siegel and Rathbone, 2012;Wilson, 2012). Modified release of an active agent from a drug delivery system includes delayed, sustained, controlled, organ targeted, or cell receptor-specific release (Perrie and Rades, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…The modified release can be further divided into prolonged/sustained, delayed, multi-step, or pulsatile release. The control or modification of the release profiles involves drug delivery systems such as nano/microparticles, polymersomes, liposomes/nanosomes, carbon nanotubes or quantum dots, colloidal drugs, and emulsions, including multiple emulsions (Lam and Gambari, 2014;Siegel and Rathbone, 2012;Wilson, 2012). The paper concerns O1/W/O2 double emulsions with two different substances for local modified delivery of an antiseptic (phenyl salicylate -salol) and an agent preventing microorganism growth (benzoic acid).…”

Section: Introductionmentioning

confidence: 99%

Chemical and Process Engineering

Markowska-Radomska,

Dluska,

Metera

et al. 2021

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Most antiseptic agents are intended for use on intact skin, e.g. for hand hygiene or skin preparation before any medical procedure. This paper presents multiple emulsion-based antiseptic agents as formulations for application to body surfaces with modified release rates.Multiple emulsions with a co-encapsulated antiseptic (phenyl salicylate -salol) and an agent preventing microorganism growth (benzoic acid) were formed in a Couette-Taylor flow apparatus. Results confirmed the possibility of the release kinetics modification while two compounds were encapsulated in the internal droplets of emulsions to control the release rates and time of the dose release. The addition of benzoic acid as a second active compound of the encapsulation process in the internal phase of double O1/W/O2 emulsion reduced the time necessary for the total release of salol triggering a two-step release.

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“…Indeed, modifying oral drug release improves the therapeutic index by maintaining the plasma drug concentration within the therapeutic window or by targeting a specific area within the gastrointestinal tract. Furthermore, this helps reduce the dose and the dosing frequency, minimizing the side effects, and therefore enhancing patients’ compliance [ 11 ]. Depending on the drug absorption windows and/or its site of action, the drug release could be designed to take place in a controlled manner in the gastric, intestinal or even colonic segments.…”

Section: Introductionmentioning

confidence: 99%

Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads

et al. 2019

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In this study, bovine serum albumin (BSA) and alginate (ALG) conjugates were synthesized by the Maillard reaction in order to evaluate their potential to develop controlled release drug delivery systems. The progress of the Maillard reaction was evidenced using ultraviolet (UV) absorbance, determination of BSA remaining free amino groups, and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). BSA-ALG conjugates possessed enhanced and tunable viscosity, foamability and foam stability. Foam generated from BSA-ALG conjugate solution was used to prepare floating gastroretentive calcium ALG beads. Unlike traditional ALG beads, BSA-ALG foam beads were able to float and sustain the ciprofloxacin (CIP) release in gastric medium. Interestingly, intestinal beads made of ALG, BSA-ALG physical mixture and BSA-ALG conjugate resulted in different release rates and orders of indomethacin (IND) in simulated intestinal fluids; while beads based on a physical mixture of BSA-ALG resulted in a first order sustained release profile, both systems based on ALG and BSA-ALG conjugate displayed zero order sustained release profiles with IND being released at a slower rate from the conjugate beads.

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The Need for Drugs and Drug Delivery Systems

Cited by 3 publications

References 2 publications

Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters

Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters

Chemical and Process Engineering

Potential Use of the Maillard Reaction for Pharmaceutical Applications: Gastric and Intestinal Controlled Release Alginate-Albumin Beads

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