The negative conversion of high-risk human papillomavirus and its performance in surveillance of cervical cancer after treatment: a retrospective study

Song, Dan; Kong, Wei­min; Zhang, Tongqing; Jiao, Simeng; Chen, Jiao; Han, Chao; Liu, Tingting

doi:10.1007/s00404-016-4197-4

Cited by 13 publications

(4 citation statements)

References 34 publications

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“…An increased variety of vaginal microbiota, combined with a reduction of Lactobacillus spp., is linked with HPV infection acquisition and persistence and development of cervical pre-cancerous lesions and after years cancer [ 15 – 17 ]. Cervical cancer is the most common cancer among women in developing countries and the second most frequent female tumour worldwide [ 16 ]. Commonly, it progresses through a sequence of premalignant lesions known as cervical intraepithelial neoplasia (CIN) 1, 2 and 3 [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection

et al. 2018

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BackgroundOver recent years, a growing interest has developed in microbiota and in the concept of maintaining a special balance between Lactobacillus and other bacteria species in order to promote women’s well-being. The aim of our study was to confirm that vaginal Lactobacilli long-lasting implementation in women with HPV-infections and concomitant bacterial vaginosis or vaginitis might be able to help in solving the viral infection, by re-establishing the original eubiosis.MethodsA total of 117 women affected by bacterial vaginosis or vaginitis with concomitant HPV-infections were enrolled at Department of Gynecological Obstetrics and Urological Sciences, La Sapienza University, Rome, Italy between February 2015 and March 2016. Women were randomized in two groups, standard treatment (metronidazole 500 mg twice a day for 7 days or fluconazole 150 mg orally once a day for 2 consecutive days) plus short-term (3 months) vaginal Lactobacillus implementation (group 1, short probiotics treatment protocol group, n = 60) versus the same standard treatment plus long-lasting (6 months) vaginal Lactobacillus rhamnosus BMX 54 administration (group 2, treatment group, n = 57).ResultsAfter a median follow up of 14 months (range 9–30 months) the chance to solve HPV-related cytological anomalies was twice higher in probiotic long-term users (group 2) versus short probiotics implementation group (group 1) (79.4% vs 37.5%, p = 0.041). Moreover, a total HPV-clearance was shown in 11.6% of short schedule probiotics implementation patients compared to a percentage of 31.2% in vaginal Lactobacilli long term users (p = 0.044), assessed as negative HPV-DNA test documented at the end of the study period.ConclusionsThe consistent percentage of clearance of PAP-smear abnormalities and HPV-clearance obtained in long-term treatment group has been interestingly high and encouraging. Obviously, larger and randomized studies are warranted to confirm these encouraging results, but we believe that eubiosis re-establishment is the key to tackle effectively even HPV-infection.Trial registrationRetrospectively registered on PRS NCT03372395 (12/12/2017).

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Section: Discussionmentioning

confidence: 99%

Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection

et al. 2018

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“…Cervical cancer is the most common neoplasia among patients in developing countries and the second most frequent female cancer worldwide [ 24 ]. Frequently, it develops through a sequence of premalignant lesions, described as different grades of CIN 1, 2 and 3 [ 22 ]; just a few women with CIN lesions undergo progression to invasive cancer.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus crispatus M247 oral administration: Is it really an effective strategy in the management of papillomavirus-infected women?

Dellino

Cascardi

Laganà

et al. 2022

Infect Agents Cancer

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Background Recent studies have shown the importance of the microbiota in women's health. Indeed, the persistence of Human Papilloma Virus (HPV)-related lesions in patients with dysbiosis can be the antechamber to cervical cancer. The aim of this study was to evaluate whether long term administration of oral Lactobacillus crispatus can restore eubiosis in women with HPV infections and hence achieve viral clearance. Methods In total, 160 women affected by HPV infections were enrolled at the Department of Gynecological Obstetrics of “San Paolo” Hospital, Italy between February 2021 and February 2022. The women were randomly assigned to two groups, one in treatment with oral Lactobacillus crispatus M247 (group 1, n = 80) versus the control group, that hence only in follow-up (Group 2, n = 80). Results After a median follow-up of 12 months (range 10–30 months), the likelihood of resolving HPV-related cytological anomalies was higher in patients in treatment with the long term oral probiotic (group 1) versus the group that perfom only follow-up (group 2) (60.5% vs. 41.3%, p = 0.05). Total HPV clearance was shown in 9.3% of patients undergoing only follow-up compared to 15.3% of patients in the group taking long term oral Lactobacillus crispatus M247 (p = 0.34). However, the percentage of HPV-negative patients, assessed with the HPV-DNA test, documented at the end of the study period was not significantly different from the control group. Conclusions Despite the limitations of our analysis, we found a higher percentage of clearance of PAP-smear abnormalities in patients who took long term oral Lactobacillus crispatus M247 than in the control group. Larger studies are warranted, but we believe that future research should be aimed in this direction. Trial registration This study is retrospectively registered.

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“…Cervical cancer represents the most common neoplasia among patients in developing countries and the second most frequent female cancer worldwide [24]. Frequently, it developments through a sequence of premalignant lesions that was described as different grade of CIN 1, 2 and 3 [22]and just a few women with CIN lesions advance in invasive cancer.…”

Section: Discussionmentioning

confidence: 99%

The Lactobacillus Crispatus M247 oral administration: it really is an effective strategy in the management of papillomavirus-infected women?

Dellino

Daniele

Vagno

et al. 2022

Preprint

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-Background: Recent studies have shown the importance of the microbiota in women's health. In contrast, a dysbiosis condition can be a predisposing condition of viral infections by Human Papilloma Virus (HPV). The persistence of HPV-related lesions in patients with dysbiosis, could represent the antechamber of cervical cancer. The aim of this study is to evaluate whether long-term administration of oral lactobacilli may allow the restoration of eubiosis in women with HPV-infections with consequently viral clearance. -Methods: A total of 160 women affected HPV-infections were enrolled at Department of Gynecological Obstetrics of “San Paolo” Hospital, Italy between February 2021 and February 2022.Women were randomized in two groups, in treatment with oral Lactobacillus Crispatus M247 (group 1, n = 80) versus controlled group, with only follow-up (Group 2 n= 80).-Results: After a median follow up of 12 months (range 10-30 months) the chance to solve HPV-related cytological anomalies was higher in treatment with oral probiotic long-term users (group 1) versus group with placebo (group 2) (60.5% vs 41,3%, p = 0.05). Furthermore, a total HPV-clearance was shown in 9,3% in patients with only follow-up compared to a percentage of 15,3 % in group that assumed oral Lactobacilli long term users (p = 0.34). So, the percentual of patients assessed with HPV-DNA test documented at the end of the study period is not significatively different by the control group.-Conclusions: Despite the limitations of our analysis, we find a higher percentage of clearance of PAP-smear abnormalities, in patients who have took oral Lactobacilli long term than the control group. These results represent a confirm that the eubiosis re-establishment could be the first step to eradicate efficiently HPV-infection. Larger studies are need yet but we believe that future researchs should act in this direction.Trial registration: This word is retrospectively registered.

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The negative conversion of high-risk human papillomavirus and its performance in surveillance of cervical cancer after treatment: a retrospective study

Cited by 13 publications

References 34 publications

Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection

Long-term Lactobacillus rhamnosus BMX 54 application to restore a balanced vaginal ecosystem: a promising solution against HPV-infection

Lactobacillus crispatus M247 oral administration: Is it really an effective strategy in the management of papillomavirus-infected women?

The Lactobacillus Crispatus M247 oral administration: it really is an effective strategy in the management of papillomavirus-infected women?

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