The negative correlation between testosterone levels and age in healthy Indonesian men residing in the special capital province of Jakarta, Indonesia

Abstract

Background: Testosterone levels in the circulation determined by production and secretion by Leydig cell in the testes. The action mechanism of testosterone to target cells mediated by sex hormone binding globulin (SHBG). The levels of testosterone and SHBG in circulation determine men's health. The objective in this study to know the relationship between testosterone, SHBG and insulin with age in healthy Indonesian men residing in the special capital province of Jakarta, Indonesia.Methods: This study is a cross-sectional study involving 250 healthy Indonesian men residing in the special capital province of Jakarta, Indonesia. Consecutive sampling was done in this study. Testosterone, SHBG and insulin in the serum were measured by immunoradiometric assay (IRMA). Glucose, triglycerides and albumin were measured using a spectrophotometer. Regression analysis was done to know the correlation between testosterone, SHBG and insulin with age.Results: The levels of TT, free testosterone (FT), SHBG and percentage of free testosterone (%FT) in healthy Indonesian men were negatively correlated with age (p<0.05). Free testosterone index (FTI) and insulin are not correlated with age (p>0.05). The levels of SHBG, FT, %FT and FTI were correlated positively with TT (p<0.05), but insulin did not correlate with TT (p>0.05). The %FT and FTI were positively correlated with FT (p<0.05), but SHBG and insulin levels did not correlate with FT (p>0.05). SHBG levels are not correlated with insulin (p>0.05). The rate of decline in TT levels in this study 9.8% per decade, while in SHBG levels 8.19% per decade.Conclusions: The levels of TT, FT, % FT and SHBG in this study were negatively correlated with age, but the FTI and insulin did not correlate with age. The rate of decline in TT levels in this study 9.8% per decade, while in SHBG levels 8.19% per decade.

Handgrip strength as an indicator of decreased cognitive function in the elderly

“…38 The results of the study are in line with the results of a study that showed that total testosterone levels were negatively correlated with age. 39 With respect to testosterone levels within the circulation, only free testosterone is available for use by target cells with intermediary sex hormone binding globulin (SHBG). 40,41 It has been demonstrated that SHBG levels in cerebrospinal fluid correlate with decreased cognitive function.…”

Role of sex steroid hormone on hand grip strength and cognitive function in the elderly

“…(78) The results of a previous study involving 250 healthy men aged 31-60 years showed that total testosterone levels were negatively correlated with increasing age. (79) The results of another study showed that the rate of decline in testosterone production by Leydig cells was about 1% per year. (80) It has been demonstrated that testosterone is important for muscle growth in youth, but testosterone is not essential for maintaining muscle mass in adult male rats.…”

Protein pengikat hormon seks: sex hormone binding globulin (SHBG) dan aksi steroid seks

“…20 Hasil penelitian terhadap pria Indonesia yang tinggal di Jakarta memperlihatkan bahwa kadar SHBG (nmol/L) mengikuti persamaan Y=48.849-0.328*umur, sedangkan testosterone total (nmol/L) mengikuti persamaan Y=28.827-(0.224*umur), dan kadar testosterone bebas (nmol/L) mengikuti persamaan Y=0.036+(0.001*testosteron total). (23) Testosteron bebas dalam sistem sirkulasi bersifat fungsional (tersedia dan dapat digunakan oleh sel sasaran), sedangkan testosteron dalam bentuk yang terikat bersifat non fungsional (tidak tersedia dan tidak dapat digunakan oleh sel sasaran). Ikatan antara SHBG dan hormon seks steroid dalam aksinya ke sel sasaran ditemukan kemudian setelah teori difusi hormon seks steroid melewati membran sel sasaran.…”