The negative impact of tobacco smoking on survival after prostate cancer diagnosis

Polesel, Jerry; Gini, Andrea; Maso, Luigino Dal; Stocco, Carmen; Birri, Silvia; Taborelli, Martina; Serraino, Diego; Zucchetto, Antonella

doi:10.1007/s10552-015-0624-2

Cited by 21 publications

(34 citation statements)

References 19 publications

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“…16,17 Briefly, 780 patients with histologically confirmed PCa diagnosed between 1995 and 2002 at the age of 46–74 years (median age: 66 years, inter-quartile range, IQR: 61–69) had been enrolled in the Pordenone area, Northeastern Italy. PCa cases were consecutive patients newly diagnosed with PCa in major local hospitals (where most of the patients with PCa are referred to for diagnosis and treatment).…”

Section: Methodsmentioning

confidence: 99%

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Dietary inflammatory index and prostate cancer survival

Gini

Shivappa

Hébert

et al. 2016

Intl Journal of Cancer

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Systemic inflammatory status has been reported to impact survival of prostate cancer (PCa) patients; however, evidence is lacking on whether the inflammatory potential of diet can influence prognosis of PCa patients. To investigate the association between a dietary inflammatory index (DII) and PCa survival, we conducted a retrospective cohort study including 726 men with PCa originally enrolled, between 1995 and 2002, in an Italian case–control study. Information on diet and Gleason score was collected at PCa diagnosis. DII was derived from a food frequency questionnaire using a validated algorithm. Adjusted hazard ratios (HRs) of death with 95% confidence intervals (CIs) were estimated using a Fine-Gray model. DII scores were not significantly associated with all-cause mortality of PCa patients (HR highest vs. lowest DII tertile = 1.25; 95% CI: 0.86–1.83). However, considerable heterogeneity emerged according to Gleason score (p < 0.01): no associations emerged among men with Gleason score 2–6 PCa; whereas, among patients with Gleason score 7–10 PCa, DII was directly associated with both all-cause and PCa-specific mortality (HR highest vs. lowest DII tertile: 2.78; 95% CI: 1.41–5.48; and 4.01; 95% CI: 1.25–12.86; respectively). Among patients with Gleason score 7–10 PCa, ten-year all-cause survival probabilities were 58% (95% CI: 47–67%) for highest and 78% (95% CI: 67–86%) for lowest DII tertile. Study findings support the hypothesis that diet, through its inflammatory potential, may influence the prognosis of patients with more aggressive PCa. Dietary interventions aimed at decreasing inflammation may be considered to improve survival of men with PCa.

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Section: Methodsmentioning

confidence: 99%

“…Patients with missing information on Gleason scores ( n = 94) reported a risk of death similar to that of patients with Gleason score 7–10. 17 …”

Section: Methodsmentioning

confidence: 99%

Dietary inflammatory index and prostate cancer survival

Gini

Shivappa

Hébert

et al. 2016

Intl Journal of Cancer

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“…A similar scenario is evident for patients treated with radiotherapy or androgen deprivation therapy [13]. Smoking at PCa diagnosis negatively impacts PCa-specific, long-term survival, regardless of Gleason score [14]. The influence of smoking on PCa screening and PSA evaluation has been also investigated, providing a great opportunity for smoking counselling [9].…”

Section: Prostate Cancermentioning

confidence: 99%

Role of cigarette smoking in urological malignancies and clinical interventions for smoking cessation

Sosnowski

Bjurlin

Verze

et al. 2016

CEJU

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IntroductionCigarette smoking is the single greatest preventable cause of disease and death. Our literature review highlights the increased risk of cigarette smoking and kidney cancer, bladder cancer and prostate cancer.Material and methodsSmoking cessation improves outcomes at all stages of these disease processes, where patients who quit for 10–20 years appear to obtain a similar risk as those who have never smoked, even after diagnosis of disease.ResultsUrologists, however, very seldom provide smoking cessation assistance. By applying brief smoking cessation intervention techniques, physicians’ posses an effective means of providing quitting advice.ConclusionsPatients who receive smoking cessation advice from their urologist are 2.3 times more likely to attempt to quit. Urologists are well-positioned to screen, counsel, and promote cessation at regular intervals, which may improve quit rates, and ultimately improve our patients’ outcomes.

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“…Gegenwärtig gibt es keine belastbare Evidenzgrundlage, einen Beitrag des Zigarettenkonsums an der Entstehung des PCA annehmen zu kön-nen [6]. Hingegen besteht eine breite Basis indirekter als auch direkter Evidenz, den Einfluss des Rauchens auf die PCA-spezifische Prognose anzuerkennen [5][6][7][8][9][10][11][12][13][14][15][16][17]. So belegen diese Studien, dass Zigarettenrauchen signifikant mit ungünstigen pathologischen Kriterien, höherer Tumorprogression (PSA-Rezidiv, Metastasen, Kastrationsresistenz) und einer höheren PCA-spezifischen Mortalität assoziiert ist [5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Studienhypotheseunclassified

“…Zudem wies dieser negative Einfluss eine signifikante Dosisabhän-gigkeit auf (Risikoratio pro 20 Zigaretten/Tag: 1,20; p = 0,02) [6]. Andererseits scheint der prognosedeterminierende Einfluss des Zigarettenkonsums dann zu verschwinden, wenn die Patienten zur Diagnosestellung bereits ≥10 Jahre Nichtraucher sind [5][6][7][8][9].…”

Section: Studienhypotheseunclassified