The Nerve Fibre Populations of the Nerves of the Leg in Chronic Occlusive Arterial Disease in Man

Garven, H. S. D.; Gairns, F. W.; Smith, Godfrey L.

doi:10.1177/003693306200700602

Cited by 53 publications

(34 citation statements)

References 10 publications

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“…Density values listed in column 4 of table I are in close conformity with those brought forth by other authors using similar means of fixation [Garven et al, 1962;Toghiet al, 1977]. Only two, that of the infant and that of the 56-year-old male, stand out by their higher values.…”

Section: Resultssupporting

confidence: 87%

“…A number of authors were prompted to collect, in addition to that of clinical cases, material for controls from normal nerves [Garven et al, 1962;Swal low, 1966;O 'Sullivan and Swallow, 1968;Dyckeet al, 1972;Behseet al, 1974;Toghi et al, 1977], Apart from findings of a qualitative nature, as related to their clinical interest, these authors provided information about numerical parameters such as axon density per square millimeter, both of myelinated and unmyelinated fibres, and, in some cases, of values for the perineurium enclosed sur face areas and absolute fibre numbers.…”

Section: Introductionmentioning

confidence: 99%

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Numerical Size Variability in the Peripheral Nerve

Tomasch¹

1983

Cells Tissues Organs

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Cross-sections of 17 sciatic nerves were examined by an image analyzer as to sum of fibre carrying cross-sectional areas and by light-microscopic visual area sampling as to myelinated and unmyelinated fibre densities. Intra-perineural cross-sectional areas range from 3.5 ×10⁶ to 7.6 ×10⁶ µm² with a mean of 5.8 ×10⁶ in the 12 male subjects and 3.4 ×10⁶ to 4.0 ×10⁶, x = 3.7 ×10⁶ µm² in 4 mature females. Estimates of total fibre content range from 6.1 × 10⁴ to 1.6 × 10⁵ in the males and 6.1 × 10⁴ to 9.2 × 10⁴ in these female subjects. Variations in axon number totals and in ratios of myelinated to unmyelinated fibre densities are not age correlated. Variations also occur in the diameter distributions of myelinated fibres and in ratios of small to large diameter myelinated fibres.

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Section: Resultssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Numerical Size Variability in the Peripheral Nerve

Tomasch¹

1983

Cells Tissues Organs

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“…The gross inflammatory reaction around the DMBA injected nerves may have produced ischaemia with subsequent segmental demyelination, similar to that occurring in the limb nerves with occlusive vascular disease in man (Garven, Gairns, and Smith, 1962;Chopra and Hurwitz, 1967;Eames and Lange, 1967).…”

Section: Discussionmentioning

confidence: 81%

Experimental hypertrophic neuropathy: an electron microscope study.

Weller¹,

Gupta²

1968

Journal of Neurology, Neurosurgery & Psychiatry

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“…5). In this su,bject it might be asked whether obliterative arterial disease could have been present in the legs to account for these changes, as in the cases described by Garven et al (1962). Although examination of the vasa nervorum in the biopsy specimen of case 23 provides no evidence of this process, it is still possible that atheromatous plotted showing the absolute numbers of fibres from 2 IL to 16 ,u in 1 ,t groups.…”

Section: Figure 2 Variation In Nibre Density Was Tound Tomentioning

confidence: 98%

“…from which we can estimate exactly the amount of loss of myelinated fibres'. However, Garven, Gairns, and Smith (1962) have questioned the reliability of the anterior tibial nerve for quantitative study, and have drawn attention to the variability of its fibre content in normal people. The present work was designed to investigate these conflicting views and to demonstrate the extent and nature of such variability.…”

mentioning

confidence: 99%