The Neural Causes of Congenital Amusia

Chen, Jian Saturn; Yuan, Jie

doi:10.1523/jneurosci.1500-16.2016

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…The copyright holder for this preprint this version posted February 4, 2024. ; https://doi.org/10.1101/2024.02.04.578219 doi: bioRxiv preprint dorsolateral prefrontal cortex engages in, even provides causal support for music perception (Albouy et al, 2018;Chen and Yuan, 2016). Combined with these findings, our results indicated elevated activity on left hemispheric homologous music circuits is a maladaptive regulation.…”

Section: Discussionsupporting

confidence: 58%

“…Increased inter-hemisphere connectivity was also reported in amusia (Albouy et al, 2013; Jin et al, 2021a). MFG_IFS is adjacent to IFG, and it was demonstrated right dorsolateral prefrontal cortex engages in, even provides causal support for music perception (Albouy et al, 2018; Chen and Yuan, 2016). Combined with these findings, our results indicated elevated activity on left hemispheric homologous music circuits is a maladaptive regulation.…”

Section: Discussionmentioning

confidence: 91%

“…In which, right superior temporal gyrus (STG) and inferior frontal gyrus (IFG) are core regions, other regions such as the right insula and inferior parietal lobule (IPL) located on both circuits also play a role in music processing. Altered function or structure in both circuits were reported (Albouy et al, 2019; Albouy et al, 2013; Chen and Yuan, 2016; Hyde et al, 2007; Jin et al, 2021a; Liao et al, 2022; Norman-Haignere et al, 2016; Sihvonen et al, 2016; Sihvonen et al, 2017a; Sihvonen et al, 2021; Sihvonen et al, 2017b; Sun et al, 2021). There is an acknowledged cognition-related interaction between structure and function, however, current studies only explored musical neural processes via multiple unimodal features separately to date.…”

Section: Introductionmentioning

confidence: 99%

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Elevated Activity in Left Homologous Music Circuits is Maladaptive for Music Perception but Mediated by Decoupled Structure and Function

Wang,

Jin,

Huyang

et al. 2024

Preprint

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Music is inherent in human life and is a significant topic of cognitive neuroscience. Previous studies focused on amusia suggested that two frontotemporal circuits engage in music processing. Structure-function coupling is an important feature of human brain, which is associated with cognition and allows for a more sensitive investigation of brain-behavior association. However, we still have limited knowledge about the relation between structure-function coupling, music processing and other regional neural profiles. We recruited 106 participants (43 subjects were diagnosed with congenital amusia) and measured their music perception by Montreal Battery of Evaluation of Amusia (MBEA). Then we utilized support vector regression algorithm and mediation analysis, and employed amplitude of low frequency fluctuation (ALFF), structural/functional degree centrality (DC) and structure-function coupling to explore their relation with global averaged MBEA score. We found structure-function coupling of widespread brain regions in both hemispheres, rather than ALFF or DC, contributed to predict MBEA score. Left middle frontal gyrus, bilateral inferior temporal gyrus and right insula were most predictive regions, and these regions were involved in memory and cognitive control according to meta-analysis. Further, coupling of left middle frontal gyrus, a region that is homologous to and is connected with typical music circuits, fully mediated the negative relation between ALFF and MBEA score. Our findings provide further understanding for the neural basis of music, and have implications for neural plasticity, neuromodulation therapy and cognitive causes of amusia.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Elevated Activity in Left Homologous Music Circuits is Maladaptive for Music Perception but Mediated by Decoupled Structure and Function

Wang,

Jin,

Huyang

et al. 2024

Preprint

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“…This finding may suggest that the impairment in pitch/lexical tone processing is likely to have no direct impact on ear preference. Previous neuroimaging studies have reported neural impairments in a RH frontotemporal network including the IFG and STG in amusia (Hyde et al, 2011;Albouy et al, 2013;Chen and Yuan, 2016;Wang et al, 2017;Zhang et al, 2017a). Additionally, a number of EEG studies suggested that the amusics' brain showed abnormal responses during attentive processing of musical pitch and lexical tones with small pitch differences (Peretz et al, 2009;Moreau et al, 2013;Zendel et al, 2015;.…”

Section: Discussionmentioning

confidence: 99%

“…As for the ear preference and how it will be affected in amusia, this remains an open question, although some speculations could be made based on the previously reported neural deficits in amusia. It has been found that neural impairments in amusia implicate a RH frontotemporal network including the inferior frontal gyrus (IFG) and superior temporal gyrus (STG) (Hyde et al, 2011;Albouy et al, 2013;Chen and Yuan, 2016;Wang et al, 2017;Zhang et al, 2017a). In addition, abnormal lack of activation in the right STG during lexical tone perception has been found in Cantonese speakers with amusia (Zhang et al, 2017a).…”

Section: Introductionmentioning

confidence: 99%

Dichotic Perception of Lexical Tones in Cantonese-Speaking Congenital Amusics

Shao

Zhang

2020

Front. Psychol.

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Congenital amusia is an inborn neurogenetic disorder of musical pitch processing, which also induces impairment in lexical tone perception. However, it has not been examined before how the brain specialization of lexical tone perception is affected in amusics. The current study adopted the dichotic listening paradigm to examine this issue, testing 18 Cantonese-speaking amusics and 18 matched controls on pitch/lexical tone identification and discrimination in three conditions: non-speech tone, low syllable variation, and high syllable variation. For typical listeners, the discrimination accuracy was higher with shorter RT in the left ear regardless of the stimulus types, suggesting a left-ear advantage in discrimination. When the demand of phonological processing increased, as in the identification task, shorter RT was still obtained in the left ear, however, the identification accuracy revealed a bilateral pattern. Taken together, the results of the identification task revealed a reduced LEA or a shift from the right hemisphere to bilateral processing in identification. Amusics exhibited overall poorer performance in both identification and discrimination tasks, indicating that pitch/lexical tone processing in dichotic listening settings was impaired, but there was no evidence that amusics showed different ear preference from controls. These findings provided temporary evidence that although amusics demonstrate deficient neural mechanisms of pitch/lexical tone processing, their ear preference patterns might not be affected. These results broadened the understanding of the nature of pitch and lexical tone processing deficiencies in amusia.

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