The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation

Lee, Christopher R.; Chen, Alon; Tye, Kay M.

doi:10.1016/j.cell.2021.02.028

Cited by 83 publications

(57 citation statements)

References 209 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Motivation is derived from need, which is the force required to conduct a particular goal-directed behaviour 25, 42, 43, 47 . However, even when the need is high, motivation only starts to arise when the following prerequisites are met : absence of conflicting needs, no state of avolition, and (most importantly) accessibility to the goal is granted 48, 49 . For example, during the freeway trip, the specific urge toward the hamburger increases only after observing the McDonald’s sign (accessibility moment).…”

Section: Supplementary Methodsmentioning

confidence: 99%

Neural Mechanism of Hunger-gated Food-seeking and Evaluating

Lee

Song

Kim

et al. 2020

Preprint

View full text Add to dashboard Cite

Agouti-related protein (AgRP) has been believed to be the main driver of feeding behaviors ever since its discovery. However, recent studies using fiber photometry and optogenetics proved that feeding behaviors are not directly driven by AgRP neurons (temporal discrepancy between neuronal activity and behavior). To resolve this paradox, we conducted novel multi-phase feeding experiments to scrutinize the dynamics of AgRP. Fiber photometry study showed that AgRP neurons start to deactivate even before the initiation of the food search phase. Using optogenetics, we could prove that the feeding behavior induced by AgRP neuron activation had substantial temporal delay and the feeding behavior was sustained for substantial time even after cessation of optogenetic activation. These results indicate that AgRP neurons are not the direct driver of feeding behavior and another downstream neuron is the driver of feeding behavior. Leptin receptor (LepR) neurons in the lateral hypothalamus (LH). LH LepR neurons were activated before voluntary food search behavior initiation and showed robust increase after food approach behavior. Artificial activation of LH LepR neurons drives food search and food approach behavior. In accordance, chemogenetic activation of LepR neurons increased food search and food approach behaviors. Lastly, slice calcium imaging results showed the possibility that NPY from the AgRP neurons could be the downstream neuromodulator of AgRP neuron, driving LH LepR neuron activation. Overall, our study shows that AgRP neurons are not the direct drivers of feeding behavior, whereas LH LepR neurons directly drive sustained food seeking behavior.

show abstract

Section: Supplementary Methodsmentioning

confidence: 99%

Neural Mechanism of Hunger-gated Food-seeking and Evaluating

Lee

Song

Kim

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Borrowing from the concept of allostasis, social health can be seen as a dynamic construct, with optimal levels that shift in response to present and anticipated future circumstances (Lee et al, 2021;Quadt et al, 2020). The same amount of social contact may become more or less adequate given other circumstances in a person's life, such as changing city or country of residence (Oishi, 2010;Watt & Badger, 2009).…”

Section: An Allostatic Approach To Social Healthmentioning

confidence: 99%

On social health: Conceptualization, Correlates and Patterning

Doyle¹,

Link²

2022

Preprint

View full text Add to dashboard Cite

Drawing upon extensive literature on the importance of social relationships from across social science and health disciplines, we propose a strong conceptualization of social health as a dynamic and multifaceted construct with the ability to expand and focus theory, research and practice. We define social health as the perceived and actual availability and quality of one’s various social relationships. Using this conceptualization, we demonstrate how a tripartite model of health, situated within the human body (and mind), best explains well-documented interrelationships between physical, psychological and social aspects of health. In order to describe the utility and importance of social health, we discuss its significance to understanding and addressing population health concerns, especially health inequalities, as well as recent major global events, including the rise of “deaths of despair” and the COVID-19 pandemic. By renewing research on social health under the framework presented herein, scholars can unify disparate lines of work on constructs ranging from loneliness and social integration to close relationship quality and social capital. Moreover, we argue that adoption of the concept of social health is critical to the success of nations, states and health systems across societies in guaranteeing an optimal state of health for all.

show abstract

“…Manipulations of the social environment through deprivation or isolation can have a bidirectional impact on behavior. Long-term social disruption can impair social learning and interaction, and shorter-term isolation can facilitate age-specific social behaviors during adolescence ( Ferrara et al, 2021b ; Kinley et al, 2021 ; Lee et al, 2021 ; Caruso et al, 2022 ). This facilitation of social behavior with brief isolation can improve social recognition memory in adolescents, while reducing it in adults, which is indexed with increased novel partner investigation relative to a familiar ( Ferrara et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, the behavioral mechanisms related to social recognition and the impact of isolation are unclear, as isolation-driven facilitation of social interaction may promote shifts in partner preference unrelated to social recognition. This same isolation can engage a network of developing brain regions and may, therefore, influence partner preference from adolescence to adulthood ( Lee et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Developmental differences in amygdala projection neuron activation associated with isolation-driven changes in social preference

Ferrara

Trask

Ritger

et al. 2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Adolescence is a developmental period characterized by brain maturation and changes in social engagement. Changes in the social environment influence social behaviors. Memories of social events, including remembering familiar individuals, require social engagement during encoding. Therefore, existing differences in adult and adolescent social repertoires and environmentally-driven changes in social behavior may impact novel partner preference, associated with social recognition. Several amygdala subregions are sensitive to the social environment and can influence social behavior, which is crucial for novelty preference. Amygdala neurons project to the septum and nucleus accumbens (NAc), which are linked to social engagement. Here, we investigated how the social environment impacts age-specific social behaviors during social encoding and its subsequent impact on partner preference. We then examined changes in amygdala-septal and -NAc circuits that accompany these changes. Brief isolation can drive social behavior in both adults and adolescents and was used to increase social engagement during encoding. We found that brief isolation facilitates social interaction in adolescents and adults, and analysis across time revealed that partner discrimination was intact in all groups, but there was a shift in preference within isolated and non-isolated groups. We found that this same isolation preferentially increases basal amygdala (BA) activity relative to other amygdala subregions in adults, but activity among amygdala subregions was similar in adolescents, even when considering conditions (no isolation, isolation). Further, we identify isolation-driven increases in BA-NAc and BA-septal circuits in both adults and adolescents. Together, these results provide evidence for changes in neuronal populations within amygdala subregions and their projections that are sensitive to the social environment that may influence the pattern of social interaction within briefly isolated groups during development.

show abstract

The neural circuitry of social homeostasis: Consequences of acute versus chronic social isolation

Cited by 83 publications

References 209 publications

Neural Mechanism of Hunger-gated Food-seeking and Evaluating

Neural Mechanism of Hunger-gated Food-seeking and Evaluating

On social health: Conceptualization, Correlates and Patterning

Developmental differences in amygdala projection neuron activation associated with isolation-driven changes in social preference

Contact Info

Product

Resources

About