The neural connectivity of the intralaminar thalamic nuclei in the human brain: A diffusion tensor tractography study

Jang, Sung Ho; Lim, Hyoung Won; Yeo, Sang Seok

doi:10.1016/j.neulet.2014.07.024

Cited by 66 publications

(52 citation statements)

References 38 publications

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“…In addition, several studies have reconstructed some portions of the ARAS three-dimensionally: the RF -the thalamus -the cerebral cortex [6,7,10,11,27]. Regarding the portion of the ARAS from the pontine RF to the hypothalamus, to the best of our knowledge, only one study has been reported so far [6].…”

Section: Discussionmentioning

confidence: 99%

“…By contrast, DTI enables three dimensional reconstruction and evaluation of the ARAS in the live human brain [7,11,27] for three-dimensional evaluation of the ARAS in patients with impaired consciousness following brain injury [6,10]. However, in these studies only some parts of the ARAS were reconstructed and no study on the neural pathway from the pontine RF to hypothalamus has been reported.…”

Section: Introductionmentioning

confidence: 99%

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The ascending reticular activating system from pontine reticular formation to the hypothalamus in the human brain: A diffusion tensor imaging study

Jang

Kwon

2015

Neuroscience Letters

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The ascending reticular activating system from pontine reticular formation to the hypothalamus in the human brain: A diffusion tensor imaging study

Jang

Kwon

2015

Neuroscience Letters

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“…The integrated information is sent from the IM and IL to the pulvinar and the intralaminar nuclei of the thalamus (Nakamura & Itoh, 2004), and then to the visual and visual association cortices, as well as the diverse cortical areas that relate arousal, attention, and sensorimotor function (Kaufman & Rosenquist, 1985a;Shipp, 2004;Wong, Collins, Baldwin, & Kaas, 2009;Jang, Lom, & Yeo, 2014). The visual and visual association areas in turn project back to the LGNv, pulvinar, lateral posterior nucleus, and the intralaminar nuclei (Updyke, 1981;Raczkowski & Rosenquist, 1983;Kaufman & Rosenquist, 1985b).…”

Section: Functional Relevancementioning

confidence: 99%

Cerebellar projections to the ventral lateral geniculate nucleus and the thalamic reticular nucleus in the cat

Nakamura

2017

J of Neuroscience Research

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The ventral lateral geniculate nucleus (LGNv) is a retinorecipient part of the ventral thalamus and in (Jones, 1985). In the cat, the LGNv is located just ventrolateral to the dorsal lateral geniculate nucleus (LGNd), the primary visual relay nucleus in the dorsal thalamus (Hayhow, 1958). Based on its cytoarchitecture and Abbreviations: CP, cerebral peduncle; HRP, horseradish peroxidase; IA, anterior interpositus nucleus of the cerebellum; IC, internal capsule; IGL, intergeniculate leaflet; IP, posterior interpositus nucleus of the cerebellum; LC, lateral nucleus of the cerebellum; LGNd, dorsal lateral geniculate nucleus;LGNv, ventral lateral geniculate nucleus; D, dorsal subdivision of the LGNv; IL, lateral intermediate subdivision of the LGNv; IM, medial intermediate subdivision of the LGNv; L, lateral subdivision of the LGNv; M, medial subdivision of the LGNv; MC, medial nucleus of the cerebellum; MGN, medial geniculate nucleus; OT, optic tract; Pg, perigeniculate nucleus; PO, posterior complex of the thalamus; Pul, pulvinar; Re, thalamic reticular nucleus; ReI, internal sector of the Re; ReX, external sector of the Re; SC, superior colliculus; Sub, subthalamic nucleus; VBA, arcuate nucleus of the ventrobasal complex; VBX, external nucleus of the ventrobasal complex; WGA-HRP, wheat germ agglutinin conjugated to horseradish peroxidase; ZI, zona incerta. SignificanceThe manuscript describes specific connectivity from the deep cerebellar nuclei to the ventral thalamic nuclei, which is known to receive direct input from the retina. The cerebellothalamic circuit could allow integration of sensory and motor information prior to its input to the cerebral cortex. It is theoretically and practically relevant because visuomotor learning is very important for the ability of human beings to function with regard to their external environment, and this study elucidates connectivity between deep brain areas necessary for passing and gating visual information and its potentially correlated motor information to the cortex.

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“…Further analysis, particularly with tractography would be needed to examine this hypothesis. Feasibility of detailed tractography within the striatum has recently been demonstrated [91,92]. It should be borne in mind that our finding is specific for autism-like symptoms as the volumes of the caudate and globus pallidus did not correlate with ADHD symptoms.…”

Section: Discussionmentioning

confidence: 59%

Decreased Left Caudate Volume Is Associated with Increased Severity of Autistic-Like Symptoms in a Cohort of ADHD Patients and Their Unaffected Siblings

et al. 2016

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Autism spectrum disorder (ASD) symptoms frequently occur in individuals with attention-deficit/hyperactivity disorder (ADHD). While there is evidence that both ADHD and ASD have differential structural brain correlates, knowledge of the structural brain profile of individuals with ADHD with raised ASD symptoms is limited. The presence of ASD-like symptoms was measured by the Children's Social Behavior Questionnaire (CSBQ) in a sample of typically developing controls (n = 154), participants with ADHD (n = 239), and their unaffected siblings (n = 144) between the ages of 8 and 29. Structural magnetic resonance imaging (MRI) correlates of ASD ratings were analysed by studying the relationship between ASD ratings and grey matter volumes using mixed effects models which controlled for ADHD symptom count and total brain volume. ASD ratings were significantly elevated in participants with ADHD relative to controls and unaffected siblings. For the entire group (participants with ADHD, unaffected siblings and TD controls), mixed effect models revealed that the left caudate nucleus volume was negatively correlated with ASD ratings (t = 2.83; P = 0.005). The current findings are consistent with the role of the caudate nucleus in executive function, including the selection of goals based on the evaluation of action outcomes and the use of social reward to update reward representations. There is a specific volumetric profile associated with subclinical ASD-like symptoms in participants with ADHD, unaffected siblings and controls with the caudate nucleus and globus pallidus being of critical importance in predicting the level of ASD-like symptoms in all three groups.

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The neural connectivity of the intralaminar thalamic nuclei in the human brain: A diffusion tensor tractography study

Cited by 66 publications

References 38 publications

The ascending reticular activating system from pontine reticular formation to the hypothalamus in the human brain: A diffusion tensor imaging study

The ascending reticular activating system from pontine reticular formation to the hypothalamus in the human brain: A diffusion tensor imaging study

Cerebellar projections to the ventral lateral geniculate nucleus and the thalamic reticular nucleus in the cat

Decreased Left Caudate Volume Is Associated with Increased Severity of Autistic-Like Symptoms in a Cohort of ADHD Patients and Their Unaffected Siblings

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