The neural correlates of low social integration as a risk factor for suicide

Cáceda, Ricardo; James, G. Andrew; Stowe, Zachary N.; Delgado, Pedro L.; Kordsmeier, Nolan C.; Kilts, Clint

doi:10.1007/s00406-019-00990-6

Cited by 19 publications

(12 citation statements)

References 66 publications

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“…Compared to patients without any history of suicide attempt and healthy controls, suicide attempters demonstrated decreased contrast in the left insula and supramarginal gyrus during the exclusion vs. inclusion condition (Olie et al, 2017). Focusing on the insula and dorsal anterior cingulate cortex, Caceda et al (2019) failed to show any differences for cerebral activation in acutely suicidal vs. non-suicidal patients and controls during the exclusion vs. inclusion condition. Neural responses in the cingulate cortex were positively correlated with physical but not psychological pain during social exclusion.…”

Section: Introductionmentioning

confidence: 77%

Prefrontal activity during experimental ostracism and daily psychache in suicide attempters

Olié

Husky

Bars

et al. 2021

Journal of Affective Disorders

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Section: Introductionmentioning

confidence: 77%

Prefrontal activity during experimental ostracism and daily psychache in suicide attempters

Olié

Husky

Bars

et al. 2021

Journal of Affective Disorders

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“…This finding differs from the consensus that low social integration is related to suicidality. 34 Moreover, loneliness has been identified as a predictive factor of assisted suicide in Switzerland. 35 Several explanations are possible for this difference.…”

Section: Discussionmentioning

confidence: 99%

“…The anterior insular response has been associated with psychological pain during social inclusion, suggesting that even during pleasurable social interactions there is a degree of impaired brain functional activity linked to psychological pain. 34 Second, some individuals might choose EAS also to protect their loved ones from the guilt and burden that could accompany their suicide or prolonged suffering. Finally, as the published care summaries contain very little information on the psychosocial and family histories, this finding could be an artefact.…”

Section: Discussionmentioning

confidence: 99%

“Nothing Hurts Less Than Being Dead”: Psychological Pain in Case Descriptions of Psychiatric Euthanasia and Assisted Suicide from the Netherlands: « Rien ne fait moins mal qu’être mort »: La douleur psychologique dans les descriptions de cas d’euthanasie et de suicide assisté psychiatrique aux Pays-Bas

et al. 2020

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Objectives: Euthanasia and assisted suicide (EAS) of individuals with mental disorders is a growing practice in several countries, including the Netherlands. Here, we aimed to identify the most frequent dimensions of and associated factors to psychological pain, which has been associated with suicidality, in individuals undergoing psychiatric EAS. Methods: An exploratory retrospective content analysis of the English translation of 66 digital case records of individuals who died by EAS in the Netherlands between 2011 and 2014 was performed. Nine standard psychological pain dimensions (irreversibility, loss of control, emptiness, emotional flooding, freezing, social distancing, narcissistic wounds, confusion, and self-estrangement), illness, and sociodemographic variables were evaluated by 2 independent raters using a premade data abstraction form (Kohen κ > 0.8 in all cases). Results: The mean number of dimensions was 4.64 ± 1.20 (median = 5), out of 9. The most frequent dimensions were irreversibility, loss of control, emptiness, and emotional flooding, in decreasing order. Past treatment refusal and the mention of social connections in case descriptions were related to the higher number of psychological pain dimensions (4.89 ± 1.24 vs. 4.31 ± 1.07, P = 0.03 and 5.05 ± 1.17 vs. 4.43 ± 1.17, P = 0.03, respectively). Emotional flooding was the only dimension specifically associated with specific psychiatric conditions, namely posttraumatic phenomena and personality disorders. Conclusions: Numerous psychological pain dimensions were detected in case descriptions of individuals who underwent EAS before the procedure. Subjective nature of the study precludes definite conclusions but suggest that future studies should explore psychological pain and the role of interventions targeting it in patients requesting EAS.

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“…[8] On fMRI, a decrease in reactivity in the insular cortex could be the risk factor for suicide. [9] However, no solid conclusion could be made. Regarding these biological methods, there are also problems of time and cost, which are problems for practical application.…”

Section: Introductionmentioning

confidence: 99%

Early Repolarization Pattern and Suicidal Risks: A Single Center Case-Control Study

Kameyama

Sugimoto

Itoh

et al. 2020

Preprint

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Background: Early repolarization pattern was reported to be associated with mental illness. However, its role in patients with the suicidal risks remains unclear. Objective: The aim of this study is to examine the frequency of Early repolarization pattern in patients with the suicidal risks compared with the age matched medical checkups. Method: A retrospective analysis of 27 patients with a history of suicide risks, including suicide attempt and nonsuicidal self-injury, and a family history of suicide. The presence of early repolarization pattern was compared in patients with suicidal risks and controls. Social and psychological factors were also compared among the patients with suicidal risks with or without Early repolarization pattern. Result: Comparing the controls, Early repolarization pattern was significantly observed in the patients (14 patients: 52%, 7 controls: 9%, P<0.001). After logistic regression including the other clinical findings among the patients and controls, the presence of Early repolarization pattern was associated with the patients with the suicidal risks (95 % confidence interval, p < 0.001). In the patients with suicide, there were no difference between the clinical factors compared with or without Early repolarization pattern. Conclusion: There could be association between Early repolarization pattern and the patients with the suicidal risks. Further studies are needed to confirm the association between suicidal risks and Early repolarization pattern.

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The neural correlates of low social integration as a risk factor for suicide

Cited by 19 publications

References 66 publications

Prefrontal activity during experimental ostracism and daily psychache in suicide attempters

Prefrontal activity during experimental ostracism and daily psychache in suicide attempters

Early Repolarization Pattern and Suicidal Risks: A Single Center Case-Control Study

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