The neural representation of 3-dimensional objects in rodent memory circuits

Burke, Sara N.; Barnes, Carol A.

doi:10.1016/j.bbr.2014.09.001

Cited by 9 publications

(4 citation statements)

References 100 publications

(176 reference statements)

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“…Thus, the prior literature is most consistent with a role for the PRC in item processing, and the finding of a context similarity effect in the PRC was unexpected. However, there is some evidence that the PRC may additionally carry some information about context, such as the locations of items in space ( Burke and Barnes, 2014 ). PRC lesions have been shown to disrupt some forms of context memory, including object–context associations ( Norman and Eacott, 2005 ), positional changes in object arrays ( Norman and Eacott, 2005 ), and contextual fear ( Bucci et al, 2002 )—although these impairments have typically been more circumscribed than those observed following PHC damage ( Norman and Eacott, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval

Ritchey

Montchal

Yonelinas

et al. 2015

eLife

138

109

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The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a 1-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information. Together, these findings suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences.DOI: http://dx.doi.org/10.7554/eLife.05025.001

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Section: Discussionmentioning

confidence: 99%

Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval

Ritchey

Montchal

Yonelinas

et al. 2015

eLife

138

109

View full text Add to dashboard Cite

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“…Four other methodological issues may be discounted as reasons for the difference in findings. (i) In the paired viewing arena the stimuli were two‐dimensional, rather than three‐dimensional as in the object arena (Burke and Barnes, ). However, this difference is unlikely to be important as recognition‐related responsiveness has been found for 3‐D objects (Zhu and Brown, ; Zhu et al, ).…”

Section: Discussionmentioning

confidence: 99%

Finding and Not Finding Rat Perirhinal Neuronal Responses to Novelty

2016

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There is much evidence that the perirhinal cortex of both rats and monkeys is important for judging the relative familiarity of visual stimuli. In monkeys many studies have found that a proportion of perirhinal neurons respond more to novel than familiar stimuli. There are fewer studies of perirhinal neuronal responses in rats, and those studies based on exploration of objects, have raised into question the encoding of stimulus familiarity by rat perirhinal neurons. For this reason, recordings of single neuronal activity were made from the perirhinal cortex of rats so as to compare responsiveness to novel and familiar stimuli in two different behavioral situations. The first situation was based upon that used in “paired viewing” experiments that have established rat perirhinal differences in immediate early gene expression for novel and familiar visual stimuli displayed on computer monitors. The second situation was similar to that used in the spontaneous object recognition test that has been widely used to establish the involvement of rat perirhinal cortex in familiarity discrimination. In the first condition 30 (25%) of 120 perirhinal neurons were visually responsive; of these responsive neurons 19 (63%) responded significantly differently to novel and familiar stimuli. In the second condition eight (53%) of 15 perirhinal neurons changed activity significantly in the vicinity of objects (had “object fields”); however, for none (0%) of these was there a significant activity change related to the familiarity of an object, an incidence significantly lower than for the first condition. Possible reasons for the difference are discussed. It is argued that the failure to find recognition‐related neuronal responses while exploring objects is related to its detectability by the measures used, rather than the absence of all such signals in perirhinal cortex. Indeed, as shown by the results, such signals are found when a different methodology is used. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.

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“…While neural representation of stationary objects has been studied systematically in the hippocampus ( Gothard et al, 1996 ; Rivard et al, 2004 ), anterior cingulate cortex ( Weible et al, 2009 , 2012 ), perirhinal cortex ( Burke et al, 2012 ; Deshmukh et al, 2012 ; Burke and Barnes, 2015 ) and medial ( Høydal et al, 2019 ) and lateral entorhinal cortex ( Deshmukh and Knierim, 2011 ; Wang et al, 2018 ), the neuronal substrate for representations of moving objects were previously assessed in only a few studies. Earlier studies reported that hippocampal neurons responded to the position of moving objects in allocentric space but they rarely assessed the responses to position of a rat relative to moving objects (for such exception see Ho et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Navigation in a Space With Moving Objects: Rats Can Avoid Specific Locations Defined With Respect to a Moving Robot

Ahuja

Lobellová

Stuchlı́k

et al. 2020

Front. Behav. Neurosci.

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Animals can organize their behavior with respect to other moving animals or objects; when hunting or escaping a predator, when migrating in groups or during various social interactions. In rats, we aimed to characterize spatial behaviors relative to moving objects and to explore the cognitive mechanisms controlling these behaviors. Three groups of animals were trained to avoid a mild foot-shock delivered in one of three positions: either in front, on the left side, or on the right side of a moving robot. We showed the rats can recognize and avoid these specific areas. The avoidance behavior specific for the left or right side of the robot demonstrated animals not only react to “simple” stimuli such as increasing noise level or growing retinal image of an approaching object, but they process their spatial position relative to the object. Using an all-white robot without prominent visual patterns that would distinguish its different sides, we showed that the behavior does not depend on responses to prominent visual patterns, but that the rats can guide their navigation according to geometrical spatial relationship relative to the moving object. Rats’ competence for navigation in space defined by a moving object resembles navigation abilities in stationary space. Recording of hippocampal single unit activity during rat’s interaction with the robot proved feasibility of the task to uncover neuronal mechanism of this type of navigation.

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The neural representation of 3-dimensional objects in rodent memory circuits

Cited by 9 publications

References 100 publications

Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval

Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval

Finding and Not Finding Rat Perirhinal Neuronal Responses to Novelty

Navigation in a Space With Moving Objects: Rats Can Avoid Specific Locations Defined With Respect to a Moving Robot

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