The neurobiology of anhedonia and other reward-related deficits

Der-Avakian, Andre; Markou, Athina

doi:10.1016/j.tins.2011.11.005

Cited by 850 publications

(665 citation statements)

References 124 publications

(124 reference statements)

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“…Anhedonia is a prominent symptom of depression. The preclinical analogues of the anhedonia scales and the procedures most commonly used to assess depression-like behaviour in rodents are the sucrose intake and preference tests (Der-Avakian and Markou, 2012). In the present study, our results confirmed that similar to fluoxetine, PSY treatment could reverse the decreased sucrose preference index, indicating a positive antidepressant-like effect of PSY.…”

Section: Discussionsupporting

confidence: 84%

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Gao

et al. 2017

Journal of Ethnopharmacology

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Ethnopharmacological relevance: There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable. Materials and Methods:In the present study, the antidepressant-like effects of PS extracts and the ethyl acetate fraction of PS extracts (PSY) were assessed using the open field test (OFT), forced swimming test (FST), and tail suspension test (TST) in mice. Furthermore, we applied a 4 consecutive weeks of chronic unpredictable mild stress (CUMS) as a model of depression in rats, followed by a sucrose preference test. Then we examined the possible mechanisms of this action.The activity of the hypothalamic-pituitary-adrenal (HPA) axis was evaluated by detecting the serum corticosterone (CORT) concentrations, and the protein expression levels of brain-derived neurotrophic factor (BDNF), the phosphorylated form CREB and ERK1/2 were detected by qRT-PCR or Western blot. Results:The results showed that PS extracts (100, 200 mg/kg) and PSY (12.5, 25, 50 mg/kg) treatment produced antidepressant-like effects in mice similar to fluoxetine (20 mg/kg), indicated by the reduced immobility time in the FST and TST, while both had no influence on the locomotor activity in the OFT. PSY treatment significantly increased sucrose preference and reduced serum CORT levels in CUMS rats. Moreover, PSY up-regulated BDNF protein levels, and increased CREB and ERK phosphorylation levels in the hippocampus on CUMS rats. Conclusions:These findings suggest that the antidepressant-like effects of PS extracts and PSY are mediated, at least in part, by modulating HPA axis, BDNF, CREB and ERK phosphorylation and expression in the hippocampus.

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Section: Discussionsupporting

confidence: 84%

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Gao

et al. 2017

Journal of Ethnopharmacology

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“…PFC regions involved in reward processing that are frequently disrupted in schizophrenia are the anterior cingulate (ACC) and OFC, with the latter an important integrator for sensory information, emotional processing and hedonic experience [52]. Thus, choice of high-taste, high energy foods may be the result of elevated hedonic thresholds requiring high levels of stimulation in order to achieve salience [53]. [55,56].…”

Section: Introductionmentioning

confidence: 99%

Cognitive deficits, obesity and disability in schizophrenia

Strassnig

Cáceda

Newcomer

et al. 2012

Translational Neuroscience

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Despite 50 years of pharmacological and psychosocial interventions schizophrenia remains one of the leading causes of disability. The inability to function in everyday settings includes deficits in performance of social, occupational, and independent living activities. Schizophrenia is also a life-shortening illness, caused mainly by poor physical health and its complications. Dysfunctional lifestyles including sedentary behavior and lack of physical activity prevail, while treatment with adipogenic antipsychotic medication interacts with poor performance in screening, monitoring, and intervention that result in shortening of life expectancies by 25-30 years. Disability interferes with self-care and medical care, further worsening physical health to produce a vicious cycle of disability. Further, the neurobiological impact of obesity on brain functioning is substantial and relevant to schizophrenia. Decision making deficits that lead to choices resulting in obesity themselves have neurobiological determinants. Simultaneous treatment of cognitive deficits and related deficits in functional skills, ubiquitous determinants of everyday functioning in schizophrenia, and targeted interventions aimed at poor physical health, especially obesity and associated comorbidities, may lead to additive or even interactive gains in everyday functioning in patients with schizophrenia not previously realized with other interventions.

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“…Für diese gibt es trotz den offensichtlichen Schwierigkeiten bezüglich der Übertragbarkeit einige interessante Ansätze [60].…”

Section: Neurokognitive Ansätzeunclassified

Update: Negativsymptome. Psychopathologie, Epidemiologie, Pathophysiologie und Behandlungsoptionen.

2013

Swiss Arch Neurol Psychiatr

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SummaryUpdate: Negative symptoms. Psychopathology, epidemiology, pathophysiology and treatment options The negative symptoms of schizophrenia include blunted affect, alogia, a sociality, avolition and anhedonia. These symptoms are back in the focus of research owing to their strong impact on the functional ability and quality of life of individuals with schizophrenia. Psychopathological research has led to a consensus about the relevant symptoms and their measurement. N eurocognitive research approaches mainly view negative symptoms as a dysfunction of goal-directed behaviour and pathophysiological processes in the underyling brain stuctures. Treatment with second generation antipsychotics as well as add-on drugs shows only moderate effect. Cognitive b ehavioural therapy approaches are promising, but there are only a few s tudies focusing on negative symptoms. This article provides an overview on the current state of research on the psychopathology, epidemiology, pathophysiology and treatment options of negative symptoms.

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The neurobiology of anhedonia and other reward-related deficits

Cited by 850 publications

References 124 publications

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Cognitive deficits, obesity and disability in schizophrenia

Update: Negativsymptome. Psychopathologie, Epidemiologie, Pathophysiologie und Behandlungsoptionen.

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