The neurobiology of autism: Theoretical applications

Schroeder, Jessica; Desrocher, Mary; Bebko, James M.; Cappadocia, M. Catherine

doi:10.1016/j.rasd.2010.01.004

Cited by 30 publications

(12 citation statements)

References 40 publications

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“…Kientz and Dunn 1997; Watling et al 2001; Ben-Sasson et al 2007; Tomcheck and Dunn 2007; Baker et al 2008; Hilton et al 2010), neurobiological deficits (e.g. Gillberg 1999; Bauman and Kemper 2005; Schroeder et al 2010), specific deficits in the capacity to feel and integrate emotions (e.g. Capps et al 1992; Leekam 2005), or to motor or facial expression deficits (e.g.…”

Section: Introductionmentioning

confidence: 99%

Emotional Responses to Odors in Children with High-Functioning Autism: Autonomic Arousal, Facial Behavior and Self-Report

Legiša

Messinger

Kermol

et al. 2012

J Autism Dev Disord

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Although emotional functioning is impaired in children with autism, it is unclear if this impairment is due to difficulties with facial expression, autonomic responsiveness, or the verbal description of emotional states. To shed light on this issue, we examined responses to pleasant and unpleasant odors in eight children (8–14 years) with high-functioning autism and 8 age-matched typically developing controls. Despite subtle differences in the facial actions of the children with autism, children in both groups had similar facial and autonomic emotional responses to the odors. However, children with autism were less likely than controls to report an emotional reaction to the odors that matched their facial expression, suggesting difficulties in the self report of emotional states.

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Section: Introductionmentioning

confidence: 99%

Emotional Responses to Odors in Children with High-Functioning Autism: Autonomic Arousal, Facial Behavior and Self-Report

Legiša

Messinger

Kermol

et al. 2012

J Autism Dev Disord

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“…It is characterized by social impairments, deficits in communication, and restricted and repetitive behavior (Rippon et al, 2007;Schroeder et al, 2010). These symptoms begin normally before a child is about three (2-4) years old (Courchesne et al, 2004;Redcay and Courchesne, 2005;Klin et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…There are several cognitive theories and models of core deficits of autism such as theory of mind deficit, executive dysfunction and the mirror neuron system model, and the weak central coherence that are not completely accepted or unified yet (Rajendran and Mitchell, 2007), although some attempts have been made in order to unify them (Schroeder et al, 2010). Also, many regions are known to be affected in autistic brain, such as social brain (amygdala, medial prefrontal cortex, and posterior superior temporal sulcus), executive functions (primarily frontal cortex) (Rippon et al, 2007;Chan et al, 2009), and brainstem (Galbraith, 2008) but its sources and how it occurs is not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Fuzzy Synchronization Likelihood-wavelet methodology for diagnosis of autism spectrum disorder

Ahmadlou¹,

Adeli

2012

Journal of Neuroscience Methods

140

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“…Se forem utilizados os critérios aceitos pela Organização Mundial de Saúde (CID, atualmente na décima edição) 12 ou pela Associação Americana de Psiquiatria (DSM, atualmente na quarta edição) 13 , esse, certamente, não é um distúrbio raro 3 . A incidência de TEA tem aumentado de forma significativa em todo o mundo 14 . O TEA ocupa o terceiro lugar entre os distúrbios do desenvolvimento, estando à frente das malformações congênitas e da síndrome de Down 3 .…”

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“…A reavaliação para características mais abrangentes, como déficits em comunicação e alterações sociais, faz com que essa concordância aumente de 60% para 92% em monozigóticos e de 0% para 10% em dizigóticos 22 . Extensas investigações revelaram o envolvimento de diferentes áreas encefálicas na gênese do TEA, incluindo estruturas do sistema límbico, amígdala, áreas pré-frontais e cerebelo 14,15,23 . As anormalidades poderiam ser induzidas em múltiplos períodos pré-natais, especialmente nas regiões cerebrais que se desenvolvem tardiamente na neurogênese.…”

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O uso de ácido valproico para a indução de modelos animais de autismo: uma revisão

Schlickmann

Fortunato

2013

J. bras. psiquiatr.

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resUMo introdução: O autismo é um distúrbio neuropsiquiátrico com base biológica significativa. Faz parte de um grupo de condições definidas como transtornos invasivos do desenvolvimento e é caracterizado de um ponto de vista comportamental, com etiologias múltiplas e graus variados de gravidade. Entre os modelos animais de autismo estudados mais extensivamente estão aqueles derivados da exposição a agentes teratogênicos. Objetivo: O objetivo deste estudo foi mostrar evidências sobre a associação entre a exposição ao ácido valproico e o desenvolvimento de sinais clínicos semelhantes aos encontrados em pacientes autistas, por meio de uma revisão de literatura. Método: Este é um artigo de revisão de literatura realizado mediante pesquisas no MedLine e SciELO. Foram utilizadas as palavras-chave "autismo", "ácido valproico" e "modelo animal de autismo". Selecionaram-se artigos publicados entre os anos de 2008 a 2012. resultados: Foi encontrado um total de 119 artigos e, desses, foram selecionados 22 artigos. Conclusão: Modelos animais gerados pela exposição de pré ou pós-natal de ácido valproico apresentam características adequadas para o estudo do autismo, principalmente porque evidenciam características comportamentais similares àquelas encontradas em indivíduos autistas. ABsTrACT introduction:Autism is a neuropsychiatric disorder with significant biological basis. Part of a group of conditions defined as pervasive developmental disorders, and is characterized from a behavioral point of view, with multiple etiologies and varying degrees of severity. Among the animal models of autism studied most extensively are those derived from exposure to teratogenic agents. Objective: The The aim of this study was to provide evidence on the association between exposure to valproic acid and the development of clinical signs similar to those found in autistic patients, through a literature review. Method: This article is a literature review conducted by searching MedLine and SciELO. We used the keyword autism, valproic acid animal model of autism. We selected articles published between the years 2008 to 2012. results: We found a total of 119 articles were selected and these 22 articles. Conclusion: Animal models generated by exposure to prenatal or postnatal valproic acid have characteristics suitable for the study of autism, mainly because behavioral traits show similar to those found in autistic individuals.

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The neurobiology of autism: Theoretical applications

Cited by 30 publications

References 40 publications

Emotional Responses to Odors in Children with High-Functioning Autism: Autonomic Arousal, Facial Behavior and Self-Report

Emotional Responses to Odors in Children with High-Functioning Autism: Autonomic Arousal, Facial Behavior and Self-Report

Fuzzy Synchronization Likelihood-wavelet methodology for diagnosis of autism spectrum disorder

O uso de ácido valproico para a indução de modelos animais de autismo: uma revisão

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