The neuroendocrine stress response and severity of acute respiratory syncytial virus bronchiolitis in infancy

Abstract

Whereas the effect of intensive care (mechanical ventilation and medication) could not be controlled for, our results suggest that there is an association between the neuroendocrine hormone response, severity of illness and degree of lymphopenia.

Glycemic level in mechanically ventilated children with bronchiolitis*

“…The high incidence of hyperglycemia (99%) in our study is similar to the incidence of hyperglycemia reported in children requiring MV and vasoactive infusion (93%) (9). Insulin resistance associated with counter-regulatory hormonal response is believed to be the mechanism involved in hyperglycemia in both settings (5,9). In RSV infection, the association between severity of illness and counter-regulatory response (5) could explain the association we now report between hyperglycemia and prolonged duration of MV and length of PICU stay.…”

“…[11-13.9] cm H 2 O, p ϭ .06). PEEP at admission was also similar between peak sustained glucose bands, and peak PEEP was higher in the HG group (6 [6 -7.5] vs. 5 [5][6] cm H 2 O) ( Table 1).…”

“…ness (5). We have now studied the significance of glucose level in children with bronchiolitis to determine whether glycemic level is associated with outcome.…”

Proteins involved in extracellular matrix dynamics are associated with respiratory syncytial virus disease severity

“…Our study confirmed the results of TASKER et al [30] who showed, in serum, that during the acute phase of RSV LRTI, infants requiring mechanical ventilation have higher growth hormone levels in plasma compared with hospitalised, nonventilated infants. This higher level of growth hormone in plasma can explain the higher level found in NPAs in this study.…”

Biology of human respiratory syncytial virus: a review

“…Other manifestations includes raised antidiuretic hormones; ADH (Hanna et al, 2003), prolactin and leptin inbalance (Tasker et al, 2004), association with hepatitis (Griffin et al, 1979), hypothermia (Njoku and Kliegman, 1993), exenthems, thrombocytopenia and conjunctivitis (Fujishima et al, 1995).…”