The neuroimaging features of Rathke's cleft cysts in children with endocrine-related diseases

Güneş, Altan; Güneş, Serra Özbal

doi:10.5152/dir.2019.19352

Cited by 13 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of RCCs could be higher in young patients with endocrine disorders. Indeed, in 958 patients under 17 years with pituitary disease (including growth hormone deficiency, CPP, multiple pituitary deficiencies, DI, idiopathic delayed puberty and hypersecretion of prolactin), RCCs were detected by MRI in 13.5% of cases 195 . A female preponderance in RCCs has been demonstrated both in adults 20,196 and in the paediatric‐adolescent population 197 .…”

Section: Rathke Cleft Cystmentioning

confidence: 99%

A clinical approach to parasellar lesions in the transition age

Sbardella

Puliani

Feola

et al. 2021

J Neuroendocrinology

View full text Add to dashboard Cite

Many reviews have summarised the pathology and management of the parasellar region in adult patients, although an analysis of these aspects in the transition years, from puberty onset to the age of peak bone mass, has been lacking. A comprehensive search of English‐language original articles, published from 2000 to 2020, was conducted in the MEDLINE database (December 2019 to March 2020). We selected all studies regarding epidemiology, diagnosis and management of the following parasellar lesions: germinoma, craniopharyngioma, Langerhans cell histiocytosis, optic glioma, hypothalamic hamartoma, tuber cinereum hamartoma, cranial chordoma, Rathke cleft cyst, hypophysitis and hypothalamitis during the transition age from childhood to adulthood. In the present review, we provide an overview of the principal parasellar lesions occurring in the transition age. Symptoms are usually a result of the mass effect of the lesions on nearby structures, as well as anterior pituitary deficits. Diabetes insipidus occurs frequently in these patients. In this age group, pubertal developmental disorders may be more evident compared to other stages of life. Parasellar lesions in the transition age mostly include neoplastic lesions such as germinomas, hamartomas, optic gliomas, craniopharyngiomas Langerhans cell histiocytosis and chordomas, and rarely inflammatory lesions (hypophysitis, hypothalamitis). There are limited data on the management of parasellar lesions in the transition age. Endocrine evaluation is crucial for identifying conditions that require hormonal treatment so that they can be treated early to improve the quality of life of the individual patient in this complex age range. The clinical approach to parasellar lesions involves a multidisciplinary effort.

show abstract

Section: Rathke Cleft Cystmentioning

confidence: 99%

A clinical approach to parasellar lesions in the transition age

Sbardella

Puliani

Feola

et al. 2021

J Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…One of the causes of hormone-related disorders in childhood physical development may be the presence of a lesion in the pituitary gland region. After endocrinological assessment, pituitary changes exclusion is one of the most important elements of diagnostic management of growth and puberty disorders (GPDs) in children [ 1 , 2 ]. The method of choice for pituitary assessment is magnetic resonance imaging (MRI) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…After endocrinological assessment, pituitary changes exclusion is one of the most important elements of diagnostic management of growth and puberty disorders (GPDs) in children [ 1 , 2 ]. The method of choice for pituitary assessment is magnetic resonance imaging (MRI) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, the MRI protocol of the pituitary gland includes images before and after administration of gadolinium-based contrast agent (GBCA) [ 2 , 11 ], which, according to current knowledge, is not neutral to the human body. Apart from the commonly known gadolinium-related side effects, such as allergic reactions as well as nephrogenic systemic fibrosis (in kidney failure) [ 12 , 13 ], the scientific literature alerts us to the possible accumulation of gadolinium compounds in some brain structures (globus pallidus and dentate nucleus) [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…These observations are of concern to the medical community and the questions are self-evident: will the developing brains of children have an increased susceptibility to long-term, potentially neurotoxic effects of GBCA deposits [ 15 , 16 ] and is it possible to limit the use of GBCA in pituitary MRI in children [ 17 , 18 ]? Additionally, the omission of GBCA administration would shorten the examination time and the duration of general anesthesia, which is necessary in the youngest patients [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MRI Protocol for Pituitary Assessment in Children with Growth or Puberty Disorders—Is Gadolinium Contrast Administration Actually Needed?

Michali-Stolarska

Tukiendorf

Zacharzewska-Gondek

et al. 2021

JCM

View full text Add to dashboard Cite

The aim of this study was to assess the diagnostic value of non-contrast pituitary MRI in children with growth or puberty disorders (GPDs) and to determine the criteria indicating the necessity to perform post-contrast examination. A retrospective study included re-analysis of 567 contrast-enhanced pituitary MRIs of children treated in a tertiary reference center. Two sets of sequences were created from each MRI examination: Set 1, including common sequences without contrast administration, and Set 2, which included common pre- and post-contrast sequences (conventional MRI examination). The differences in the visibility of pituitary lesions between pairs of sets were statistically analyzed. The overall frequency of Rathke’s cleft cysts was 11.6%, ectopic posterior pituitary 3.5%, and microadenomas 0.9%. Lesions visible without contrast administration accounted for 85% of cases. Lesions not visible before and diagnosed only after contrast injection accounted for only 0.18% of all patients. Statistical analysis showed the advantage of the antero-posterior (AP) pituitary dimension over the other criteria in determining the appropriateness of using contrast in pituitary MRIs. The AP dimension was the most significant factor in logistic regression analysis: OR = 2.23, 95%CI, 1.35–3.71, p-value = 0.002, and in ROC analysis: AUC: 72.9% with a cut-off value of 7.5 mm, with sensitivity/specificity rates of 69.2%/73.5%. In most cases, the use of gadolinium-based contrast agent (GBCA) in pituitary MRI in children with GPD is unnecessary. The advantages of GBCA omission include shortening the time of MRI examination and of general anesthesia; saving time for other examinations, thus increasing the availability of MRI for waiting children; and acceleration in their further clinical management.

show abstract