The neuropeptide FMRFamide can protect cells against apoptosis in the snail digestive gland

Röszer, Tamás; Kappelmayer, János; Gg, Nagy; Aj, Szentmiklósi; Ag, Basnak'ian; Bánfalvi, Gáspár

doi:10.1007/s10495-006-3391-4

Cited by 12 publications

(4 citation statements)

References 16 publications

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“…PrRP is also found to influence human lymphocyte proliferation ( 153 ). In invertebrates, FMRFa has been found to inhibit apoptosis in a snail, indicating that the link between RFa and apoptosis is an evolutionary conserved mechanism ( 154 ). Interestingly, NPFF gene expression in mammals is regulated by transcription factors also involved in cell-cycle regulation and apoptosis ( 155 ).…”

Section: Discussionmentioning

confidence: 99%

RFamide Peptides in Early Vertebrate Development

et al. 2014

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RFamides (RFa) are neuropeptides involved in many different physiological processes in vertebrates, such as reproductive behavior, pubertal activation of the reproductive endocrine axis, control of feeding behavior, and pain modulation. As research has focused mostly on their role in adult vertebrates, the possible roles of these peptides during development are poorly understood. However, the few studies that exist show that RFa are expressed early in development in different vertebrate classes, perhaps mostly associated with the central nervous system. Interestingly, the related peptide family of FMRFa has been shown to be important for brain development in invertebrates. In a teleost, the Japanese medaka, knockdown of genes in the Kiss system indicates that Kiss ligands and receptors are vital for brain development, but few other functional studies exist. Here, we review the literature of RFa in early vertebrate development, including the possible functional roles these peptides may play.

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Section: Discussionmentioning

confidence: 99%

RFamide Peptides in Early Vertebrate Development

et al. 2014

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“…It has been shown that apoptosis in molluscs occurs not only during embryogenesis and metamorphosic development (Gifondorwa and Leise 2006), but it is a physiological phenomenon upon exposure to toxicants and other environmental stressors (Chabicovsky et al 2004;Gaitanaki et al 2004;Kefaloyianni et al 2005;Labieniec and Gabryelak 2007;Roszer et al 2006;Russo and Madec 2007). Caspase-like activity has also been described as essential for synaptic plasticity in Helix pomatia (Bravarenko et al 2006).…”

Section: Discussionmentioning

confidence: 99%

PACAP Has Anti-apoptotic Effect in the Salivary Gland of an Invertebrate Species, Helix pomatia

et al. 2008

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Pituitary adenylate cyclase activating polypeptide (PACAP) shows a remarkable sequence similarity among species and several studies provide evidence that the functions of PACAP have also been conserved among vertebrate species. Relatively little is known about its presence and functions in invertebrates. The aim of the present study was to investigate whether the well-known anti-apoptotic effect of PACAP can also be demonstrated in invertebrates. This effect was studied in the salivary gland of a molluscan species, Helix pomatia. In this work, we first showed the presence of PACAP-like immunoreactivity in the Helix salivary gland by means of immunohistochemistry. Radioimmunoassay measurements showed that PACAP38-like immunoreactivity dominated in the salivary gland of both active and inactive snails and its concentration was higher in active than in inactive animals in contrast to PACAP27-like immunoreactivity, which did not show activity-dependent changes. PACAP induced a significant elevation of cAMP level in salivary gland extracts. Application of apoptosis-inducing agents, dopamine and colchicine, led to a marked increase in the number of terminal uridine deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive apoptotic cells in the salivary gland, which was significantly attenuated by PACAP treatment. In a similar manner, the number of caspase-positive cells was reduced after co-application of dopamine and PACAP. Taken together, the data indicate that PACAP activates cAMP in a molluscan species and we show, for the first time, that PACAP is anti-apoptotic in the invertebrate Helix pomatia.

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“…The protective effect of the PACAP is not unique, because it was reported that molluscan endogenous peptide FMRFa exerted a similar action on the midintestinal gland of the snail, Helix lucorum, indicating that FMRFa may be involved in the control of cell proliferation and apoptosis [46]. Cell cycle analysis revealed that FMRFa significantly elevated the number of cells in G 0 /G 1 phase, but did not induce mitosis.…”

Section: Salivation (Secretion)mentioning

confidence: 96%

Apoptosis and its functional significance in molluscs

Kiss

2010

Apoptosis

153

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Programmed cell death leading to apoptosis is essential for normal development and homeostasis in plants and throughout the animal kingdom. Although there are differences in apoptotic mechanisms between lower animals and vertebrates, crucial biochemical components of the programmed cell death pathways remained remarkably conserved throughout evolution. Despite decades of studies on the neurobiology and development of mollusks, comparatively little is known about the mechanisms of apoptosis in this phylum. In this review, an attempt is made to summarize data obtained on mollusks so far, and to discuss the molecular mechanisms, the functional and ecological significance of apoptosis and the advantages of snail preparations as tools for programmed cell death research. A definitive comparison of the data obtained on mollusks with those obtained on the more widely studied vertebrates, will contribute to the better understanding of the apoptotic process in general and of its evolutionary development.

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The neuropeptide FMRFamide can protect cells against apoptosis in the snail digestive gland

Cited by 12 publications

References 16 publications

RFamide Peptides in Early Vertebrate Development

RFamide Peptides in Early Vertebrate Development

PACAP Has Anti-apoptotic Effect in the Salivary Gland of an Invertebrate Species, Helix pomatia

Apoptosis and its functional significance in molluscs

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