COVID-19 pandemic has radically impacted and altered the lives of billions of people around the world. Due to strict government policies, most individuals now find themselves confined at home with limited movement permissible. Although these measures are enforced to help abate the rate of infection, such restrictions have huge implications for the psychophysiological health, lifestyle, and overall well-being of individuals. The COVID-19 confined circumstances, coupled with the gradually declining levels of physical activity and rising levels of sedentarism that is prevalent in the modern society, can have deleterious effect on the psychological, physical, and social health of individuals. This paper argues for essential alternative measures to be introduced that would not only assuage the detrimental effects of COVID-19 confinement, physical inactivity, and sedentarism in the short-term, but also promote psychophysiological health and well-being in the long-term. In particular, this paper recommends the practice of mindfulness as a viable option under the current circumstances. This paper further outlines the health benefits of mindfulness practice and illustrates two effective and efficient practices — mindful breathing and mantram chanting — that could be suitably utilized under the current altered and confined COVID-19 arrangement by individuals across the life span. Potential benefits, recommendations, and risks have also been addressed.