The Neuropilins Multifunctional Semaphorin and VEGF Receptors that Modulate Axon Guidance and Angiogenesis

The New Era of the Lymphatic System: No Longer Secondary to the Blood Vascular System

“…COUP-TFII deficiency at a late developmental stage not only reversed the LEC differentiation program, ending up regaining the blood endothelial cell fate, but also impaired lymphatic vessel sprouting, indicating the essential roles of COUP-TFII in lymphatic development (Lin et al 2010). Notably, it has been shown that the VEGF coreceptors neuropilin (NRP)-1 and NRP-2 are differentially expressed in endothelial cell lineages: Whereas NRP-1 is selectively expressed in the arterial compartment, NRP-2 is predominantly in venous and lymphatic endothelial cells (Herzog et al 2001;Neufeld et al 2002;Yuan et al 2002). COUP-TFII plays a key part in this endothelial cell-lineage-specific expression of NRP-1 and NRP-2 (You et al 2005;Lee et al 2009;Lin et al 2010).…”

Pulmonary Epithelial Neuropilin-1 Deletion Enhances Development of Cigarette Smoke–induced Emphysema

“…Two members of the neuropilin family have been identified, neuropilin-1 (Nrp1) and neuropilin-2 (Nrp2) (7). Both were initially identified as specific neuronal receptors for a class of secreted signaling proteins, the class 3 semaphorins (Sema3), which guide axonal growth cone collapse (7,(10)(11)(12). Neuropilins are also widely expressed in nonneuronal tissue, including epithelium and endothelium, and Nrp1 gene expression has been described in tissue homogenate from lung, heart, placenta, skeletal muscle, kidney, pancreas, liver, and brain (13,14).…”

Vascular endothelial growth factors (VEGF): role in pathological processes

“…Также существует два нети-розинкиназных рецептора, усиливающих активационный сигнал, но не передающих его в клетку. Это нейролипин-1 (NRP-1) и нейролипин-2 (NRP-2), при этом NRP-1 явля-ется корецептором VEGFR2, а NRP-2 -корецептором VEGFR3 [6,7].…”