The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease

Bae, Na-Young; ahn, TaekWon; Chung, Sungkwon; Oh, Myung Sook; Ko, Hyeonseok; Oh, Han-Jin; Park, Gunhyuk; Yang, Hyun Ok

doi:10.1016/j.jep.2010.12.016

Cited by 61 publications

(36 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) assay was conducted to evaluate the cytotoxicity of zinc aluminum nanomaterial containing levodopa on PC12 cell line as an in vitro model for Parkinson’s disease, a widely used cell line with neuronal characteristics [8,12,13]. The ZAL, ZA nano delivery systems with and without levodopa (respectively) and the pristine levodopa (LV) showed dose and time dependent cell viability effects.…”

Section: Resultsmentioning

confidence: 99%

Toxicity and Metabolism of Layered Double Hydroxide Intercalated with Levodopa in a Parkinson’s Disease Model

Kura

Ain

Hussein

et al. 2014

IJMS

View full text Add to dashboard Cite

Layered hydroxide nanoparticles are generally biocompatible, and less toxic than most inorganic nanoparticles, making them an acceptable alternative drug delivery system. Due to growing concern over animal welfare and the expense of in vivo experiments both the public and the government are interested to find alternatives to animal testing. The toxicity potential of zinc aluminum layered hydroxide (ZAL) nanocomposite containing anti-Parkinsonian agent may be determined using a PC 12 cell model. ZAL nanocomposite demonstrated a decreased cytotoxic effect when compared to levodopa on PC12 cells with more than 80% cell viability at 100 μg/mL compared to less than 20% cell viability in a direct levodopa exposure. Neither levodopa-loaded nanocomposite nor the un-intercalated nanocomposite disturbed the cytoskeletal structure of the neurogenic cells at their IC50 concentration. Levodopa metabolite (HVA) released from the nanocomposite demonstrated the slow sustained and controlled release character of layered hydroxide nanoparticles unlike the burst uptake and release system shown with pure levodopa treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Toxicity and Metabolism of Layered Double Hydroxide Intercalated with Levodopa in a Parkinson’s Disease Model

Kura

Ain

Hussein

et al. 2014

IJMS

View full text Add to dashboard Cite

show abstract

“…In MPTP mice models of PD, some traditional formulations such as Yi-Gan San (Doo et al, 2010), Chunghyuldan , Toki-to (Sakai et al, 2007), Zhen-Wu-Tang (Li et al, 2010b, modified Yeoldahanso-tang (Bae et al, 2010) and Bak Foong pill (Liu et al, 2004(Liu et al, , 2008a) have shown to be neuroprotective and rescued dopaminergic neurons from degeneration. Given that the pathogenesis of PD could not be single factor-derived, therapies based on single drugs are not likely to provide measurable disease modification or neuroprotection in PD.…”

Section: Herbal Extracts and Formulations With Anti-parkinsonian Actimentioning

confidence: 99%

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

Song

Sze

et al. 2012

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…As known, Parkinson’s disease (PD) is resulted by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) of midbrain (Bae et al ., 2011). Preventing aggregated and misfolded proteins in brain blocked the progression of PD which may propose a potential therapeutic benefit (Pan et al ., 2008a; Bae et al ., 2011).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells

Kim

Kang

et al. 2014

Biomolecules & Therapeutics

Self Cite

View full text Add to dashboard Cite

Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome. Autophagy plays an important role of death-survival decisions in neuronal cells, which may influence to several neurodegenerative disorders including Parkinson’s disease. Chebulagic acid, the major constituent of Terminalia chebula and Phyllanthus emblica, is a benzopyran tannin compound with various kinds of beneficial effects. This study was performed to investigate the autophagy enhancing effect of chebulagic acid on human neuroblastoma SH-SY5Y cell lines. We determined the effect of chebulagic acid on expression levels of autophago-some marker proteins such as, DOR/TP53INP2, Golgi-associated ATPase Enhancer of 16 kDa (GATE 16) and Light chain 3 II (LC3 II), as well as those of its upstream pathway proteins, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR) and Beclin-1. All of those proteins were modulated by chebulagic acid treatment in a way of enhancing the autophagy. Additionally in our study, chebulagic acid also showed a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induced cytotoxicity which mimics the pathological symptom of Parkinson’s disease. This effect seems partially mediated by enhanced autophagy which increased the degradation of aggregated or misfolded proteins from cells. This study suggests that chebulagic acid is an attractive candidate as an autophagy-enhancing agent and therefore, it may provide a promising strategy to prevent or cure the diseases caused by accumulation of abnormal proteins including Parkinson’s disease.

show abstract

The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease

Cited by 61 publications

References 30 publications

Toxicity and Metabolism of Layered Double Hydroxide Intercalated with Levodopa in a Parkinson’s Disease Model

Toxicity and Metabolism of Layered Double Hydroxide Intercalated with Levodopa in a Parkinson’s Disease Model

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells

Contact Info

Product

Resources

About