The neurotoxic impact of subchronic exposure of male rats to copper oxychloride

Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats

“…The liver of rats treated with CuQ showed histopathological changes, such as dilatation of the sinusoidal spaces, congestion of the centro-lobular vein, infiltration of inflammatory lymphocyte and Kupffer cells, and cell necrosis; previous reports have demonstrated that copper fungicides induced histopathological changes in hepatic tissues (Ghonimi et al, 2022; El-Hak and Mobarak, 2019). In our investigation, the treatment with CuQ induced dose-dependent pathological changes in kidneys as evidenced by tubular and glomerular degeneration and tubular necrosis.…”

“…The large use of pesticides has raised concerns about the risks of harmful residues in crops, affecting human health and environmental safety (Mesnage and Séralini., 2018). The general population is commonly exposed to pesticides via direct contact or ingestion of contaminated water and food, causing consequently serious health problems such as neurotoxicity (El-Hak and Mobarak., 2019), carcinogenicity (Greim el al., 2015), and nephro-hepatotoxicity (Tichati et al, 2020; Trea et al, 2022). Pesticides can induce oxidative stress by the generation of reactive oxygen species (ROS) (Devan et al, 2015), that are able to alter the vital cell components and intrinsic membrane properties like ion transport, DNA damage, etc., resulting in cell death (Halliwell and Gutteridge, 1990), and cell lipid peroxidation (Mahajan et al, 2018).…”

“…Copper is an important trace element for aerobic living organisms with significant functions in oxidation-reduction catalysis, which requires a specific intracellular and molecular handling to organismal levels of homeostatic control (Barber et al, 2021), but excess copper has a deleterious effect on organisms through induction of generation of free radical production in the living cell, lipid peroxidation, and it could disrupt the balance of the oxidation and antioxidant systems when the amount of ROS accumulated, resulting in oxidative damages (Husain and Mahmood, 2019) Several studies have shown that excessive Cu results in the inhibition of the levels of antioxidant enzymes while promoting the levels of lipid peroxidation in the liver and kidneys (Wan et al, 2020;Yang et al, 2018). As reported (You et al, 2001), copper fungicides cause oxidative DNA damage in cells, and potential teratogenicity (Elalfy et al, 2019), neurotoxicity (El-Hak and Mobarak., 2019), and hepatotoxicity (Anreddy, 2018). However, there are limited studies about chronic copper quinolate toxicity in the liver and kidney at low doses.…”

Chemotherapeutic Management of Ralstonia Solanacearum Causing Bacterial Wilt of Tomato

“…Copper-based chemicals have been widely utilized for plant protection over time, such as copper hydroxide and copper oxychloride causing copper deposition in agricultural soils (El-Hak and Mobarak, 2019). Copper is a crucial element that degrades protein function by affecting nucleic acids, thus inhibiting microbial activity (Zhang et al, 2018).…”

Histological study on the acute injection of aluminum sulfate on different organs of rats

“…Then, Rats were sacrificed by decapitation. Part of the forebrains, heart, lung, liver, kidney, spleen, stomach, small intestine epidydimis, testes, uterus and ovary were isolated and fixed in 10 % of phosphate buffered formalin for 2 days for histological preparation for light microscopic examination [EL-Hak, Moustafa [15,16,17]. 0.5 g of each rat tissue was used for the assessment of aluminum concentrations [18].…”