The Neutrophil: A Beautiful Beast or a Beastly Beauty?

From Starfish Oocytes to Inflammation: The Unforeseeable Destiny of Roscovitine in Cystic Fibrosis

“…While originally roscovitine was believed to exert its effects mainly on proliferating cells, Adriano Rossi and his colleagues (University of Edinburgh) reported that roscovitine also affected neutrophils, key cells in innate immunity deprived of proliferative capacities [5,6,7,8,9,10]. They discovered that roscovitine could trigger apoptosis of neutrophils, thereby favoring their phagocytosis by macrophages to promote the resolution of inflammation [11].…”