The Neutrophilic Granulocyte

Benestad, Haakon B.; Lærum, Ole Didrik

doi:10.1007/978-3-642-73855-5_2

Cited by 36 publications

(32 citation statements)

References 98 publications

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“…Neutrophils have a bactericidal action through phagocytosis of various foreign bodies using ROS and play an important role in the host defense system (7)(8)(9)(10). On the other hand, the …”

Section: Introductionmentioning

confidence: 99%

Effects of 2.5‐hour sumo training on serum opsonic activity

et al. 2009

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Sumo is a traditional Japanese sport, but the effect of actual daily training on neutrophil function is unknown. We evaluated the effect of sumo training on serum opsonic activity (SOA), which is one of the main neutrophil-related functions. Seventeen male university sumo wrestlers participated in the study. Changes in anthropometric parameters, concentrations of serum immunoglobulins (IgG, IgA and IgM), complements (C3 and C4), myogenic enzymes (lactate dehydrogenase, asparate aminotransferase, alanine aminotransferase and creatine kinase), white blood cell/neutrophil counts and SOA were measured immediately before and after actual daily training for 2.5 h. Compared with the pre-values, immunoglobulins and complements, myogenic enzymes and white blood cell/neutrophil counts significantly increased (p < 0.01 for all). As for SOA, the values of the peak height and the area under the curve significantly increased after the training when assessed using lucigenin as a chemiluminigenic probe (p < 0.01 for all), but showed no significant change when luminol was used as the chemiluminigenic probe. In conclusion, daily actual sumo training for 2.5 h increases SOA, thus possibly activating the reactive oxygen species production of neutrophils.

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Section: Introductionmentioning

confidence: 99%

Effects of 2.5‐hour sumo training on serum opsonic activity

et al. 2009

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“…Neutrophils play an important role in the immune system, forming the first defence against invading microorganisms (7) by phagocytosis and production of cytotoxins, such as reactive oxygen species (ROS) and lysosomal enzymes (8). Neutrophil function can be influenced by exercise and energy restriction.…”

Section: Introductionmentioning

confidence: 99%

Effects of weight reduction on neutrophil phagocytic activity and oxidative burst activity in female judoists

et al. 2003

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This study investigated the effects of short-term weight reduction on neutrophil functions in female judoists. Sixteen actively competing female judoists were divided into two groups. Eight who required weight reduction were defined as the weight reduction group, and the remaining eight were used as the control. Blood samples were taken before, immediately after and 8 days after the match. Phagocytic activity and oxidative burst activity of neutrophils were measured by flow cytometry. In the weight reduction group, the phagocytic activity per cell decreased significantly at the end of weight reduction compared with the control group. The rate of neutrophils producing reactive oxygen species and the oxidative burst activity per cell increased significantly at the end of weight reduction in both the control and the weight reduction groups. We concluded that weight reduction, consisting of both intense exercise and energy restriction, might possibly cause both an increase in oxidative burst activity and decrease in neutrophil phagocytic activity in female judoists. However, although exercise increased oxidative burst activity, it did not affect neutrophil phagocytic activity alone. Therefore, to avoid this problem, female judoists are recommended to keep their weight within those limits determined by their class, and which can be reduced by exercise.

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“…These findings clearly indicate that the protective capacity in the neutrophil is far smaller than it is in the macrophage. much faster than the monocytes/macrophages [13]. Such differentiation is stimulated by so-called "colony-stimulating" factors (such as interleukin 3 [IL-3], granulocyte macrophage colony-stimulating factor [GM-CSF], granulocyte colony-stimulating factor [G-CSF], and macrophage colony-stimulating factor [M-CSF]) [14][15][16].…”

Section: Resultsmentioning

confidence: 99%

Free Radicals and Detoxification Enzymes of Inflammatory Peritoneal Neutrophils and Macrophages.

Alaudeen¹,

Weidemann²

1997

J. Clin. Biochem. Nutr.

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SummaryIn our study to elucidate the biochemical basis of macrophage activation, we noted a transient surge (within 24 h) in neutrophil number in the peritoneal cavity following the injection of thioglycollate. By day 2 the peritoneal cell population consisted predominantly of vacuolated macrophages. In order to understand the possible cause of the above short-lived increase in neutrophils, we compared the capacity to produce toxic free radicals (by measuring luminol-dependent chemiluminescence) and the activities of detoxification enzymes, namely, glutathione peroxidase and glutathione reductase, between neutrophils (day-1 cells) and the day-2 cells, which were predominantly macrophages. The results show that the neutrophils obtained 1 day after elicitation by thioglycollate produced an intense burst of luminol-dependent chemiluminescence, approximately 7-fold greater than that of the day-2 macrophages. This was true despite a markedly enhanced oxygen consumption by the latter compared with that by the neutrophils. In addition there were marked differences in the onset and duration of the response. Investigations on the activities of detoxification enzymes, especially glutathione peroxidase and glutathione reductase, which are known to be coupled to the oxidative segment of the pentose phosphate pathway, revealed neutrophils to have a reduced capacity to detoxify free radicals and peroxides in comparison with elicited macrophages. These findings suggest that the neutrophils, despite their enhanced capacity to emit toxic free radicals and peroxides, are less efficient in protecting themselves, which ultimately may cause cell death and, as a consequence, a decline in their cell number at the site of inflammation.

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The Neutrophilic Granulocyte

Cited by 36 publications

References 98 publications

Effects of 2.5‐hour sumo training on serum opsonic activity

Effects of 2.5‐hour sumo training on serum opsonic activity

Effects of weight reduction on neutrophil phagocytic activity and oxidative burst activity in female judoists

Free Radicals and Detoxification Enzymes of Inflammatory Peritoneal Neutrophils and Macrophages.

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