The New Era of Spinal Surgery: Exploring the Use of Exoscopes as a Viable Alternative to Operative Microscopes–A Systematic Review and Meta-Analysis

Begagić, Emir; Pugonja, Ragib; Bečulić, Hakija; Selimović, Edin; Skomorac, Rasim; Saß, Benjamin; Pojskić, Mirza

doi:10.1016/j.wneu.2023.11.026

Cited by 7 publications

(4 citation statements)

References 93 publications

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“…The application of AR technology in this context has significant implications for SB surgery, enabling precise surgical planning and achieving radical resection in certain neoplasm forms such as gliomas [68][69][70][71]. Given the complexity of SB surgery in neurosurgery, educational challenges for young neurosurgeons are common [72]. The use of AR has facilitated education in intracranial pathological entities in surgery overall [73][74][75].…”

Section: Discussionmentioning

confidence: 99%

Augmented Reality Integration in Skull Base Neurosurgery: A Systematic Review

Begagić,

Bečulić,

Pugonja

et al. 2024

Medicina

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Background and Objectives: To investigate the role of augmented reality (AR) in skull base (SB) neurosurgery. Materials and Methods: Utilizing PRISMA methodology, PubMed and Scopus databases were explored to extract data related to AR integration in SB surgery. Results: The majority of 19 included studies (42.1%) were conducted in the United States, with a focus on the last five years (77.8%). Categorization included phantom skull models (31.2%, n = 6), human cadavers (15.8%, n = 3), or human patients (52.6%, n = 10). Microscopic surgery was the predominant modality in 10 studies (52.6%). Of the 19 studies, surgical modality was specified in 18, with microscopic surgery being predominant (52.6%). Most studies used only CT as the data source (n = 9; 47.4%), and optical tracking was the prevalent tracking modality (n = 9; 47.3%). The Target Registration Error (TRE) spanned from 0.55 to 10.62 mm. Conclusion: Despite variations in Target Registration Error (TRE) values, the studies highlighted successful outcomes and minimal complications. Challenges, such as device practicality and data security, were acknowledged, but the application of low-cost AR devices suggests broader feasibility.

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Section: Discussionmentioning

confidence: 99%

Augmented Reality Integration in Skull Base Neurosurgery: A Systematic Review

Begagić,

Bečulić,

Pugonja

et al. 2024

Medicina

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“…The microsurgical translaminar approach is an approach to the lumbar hidden zone and is a good option for patients with cranially and laterally migrated LDH -it is a good and cost-effective option for countries where endoscopic and/or exoscopic equipment is not widely available and used [2]. Vanni et al suggested the use of this approach when MRI imaging shows a herniated fragment that is cranially migrated in the preforaminal or foraminal zone, called the "second window of McCulloch" [3,4].…”

Section: Discussionmentioning

confidence: 99%

“…In 1998, Di Lorenzo et al proposed a novel surgical technique that preserves the facet joint, the ligamentum flavum, and the epidural soft tissues [1]. This approach was met with skepticism regarding the technical difficulty, the risk of pars interarticularis fracture, and the supposed inability to execute a microdiscectomy, as well as the poor visual control of the nerve root and the epidural bleeding [2]. Further studies show that this approach is gaining new momentum as a method to access cranially and laterally migrated LDH and the lumbar hidden zone [3].…”

Section: Introductionmentioning

confidence: 99%

The Microsurgical Translaminar Approach: A Technical Note

Cekov,

Vezirska

2024

Cureus

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Lumbar disc herniation (LDH) is a very common cause of low back pain and unilateral radiculopathy. This pathology is traditionally approached via interlaminotomy with variable amounts of bony extensions, such as partial or total facetectomy and disturbance of soft tissue structures. However, the extensive bone removal may be the cause of spinal instability, thus necessitating lumbar fusion procedures in the longer-term perspective. A novel surgical technique that spares the facet joint, the ligamentum flavum, and the epidural soft tissues was previously proposed. We present a detailed overview of the microsurgical translaminar approach for large LDH.

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“…CRISPR-Cas9 stands out as the preferred choice for editing genes or genomes in various cancers, including GBM [12][13][14][15]. Considering the current trend in medical research towards more accessible treatments for diverse pathologies [16], with an aim for broader applicability and treatment options in low-and middle-income countries [17], the potential for gene editing using this method has emerged, even in cases of GBM. There are evident studies employing this method for treating GBM, although the data are dispersed across individual studies.…”

Section: Introductionmentioning

confidence: 99%

CRISPR/Cas9-Mediated Gene Therapy for Glioblastoma: A Scoping Review

Begagić,

Bečulić,

Đuzić

et al. 2024

Biomedicines

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This scoping review examines the use of CRISPR/Cas9 gene editing in glioblastoma (GBM), a predominant and aggressive brain tumor. Categorizing gene targets into distinct groups, this review explores their roles in cell cycle regulation, microenvironmental dynamics, interphase processes, and therapy resistance reduction. The complexity of CRISPR-Cas9 applications in GBM research is highlighted, providing unique insights into apoptosis, cell proliferation, and immune responses within the tumor microenvironment. The studies challenge conventional perspectives on specific genes, emphasizing the potential therapeutic implications of manipulating key molecular players in cell cycle dynamics. Exploring CRISPR/Cas9 gene therapy in GBMs yields significant insights into the regulation of cellular processes, spanning cell interphase, renewal, and migration. Researchers, by precisely targeting specific genes, uncover the molecular orchestration governing cell proliferation, growth, and differentiation during critical phases of the cell cycle. The findings underscore the potential of CRISPR/Cas9 technology in unraveling the complex dynamics of the GBM microenvironment, offering promising avenues for targeted therapies to curb GBM growth. This review also outlines studies addressing therapy resistance in GBM, employing CRISPR/Cas9 to target genes associated with chemotherapy resistance, showcasing its transformative potential in effective GBM treatments.

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The New Era of Spinal Surgery: Exploring the Use of Exoscopes as a Viable Alternative to Operative Microscopes–A Systematic Review and Meta-Analysis

Cited by 7 publications

References 93 publications

Augmented Reality Integration in Skull Base Neurosurgery: A Systematic Review

Augmented Reality Integration in Skull Base Neurosurgery: A Systematic Review

The Microsurgical Translaminar Approach: A Technical Note

CRISPR/Cas9-Mediated Gene Therapy for Glioblastoma: A Scoping Review

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