The New Target of Vulnerable Plaque

Oshima, Tomokazu; Fujiu, Katsuhito

doi:10.1536/ihj.20-674

Cited by 1 publication

(1 citation statement)

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“…Studies have shown that plaque rupture with thrombosis is a common pathological form of severe heart disease, while vulnerable plaque is its early manifestation. [ 87 ] Vulnerable plaque refers to vulnerable plaques prone to thrombosis and likely to develop rapidly into criminal plaques, with pathological features such as thin fibrous caps, large necrotic lipid cores, abundant inflammatory cells, and a small amount of smooth muscle cells. [ 88 ] It can be inferred that the stability of AS plaque is negatively correlated with the number of inflammatory cells and the size of necrotic lipid core, while it is positively correlated with the thickness of fibrous cap.…”

Section: Plaque Rupture Stage: Inflammatory Cells and Vulnerable Plaquesmentioning

confidence: 99%

Inflammatory factors driving atherosclerotic plaque progression new insights

Song

Bie

Feng

et al. 2022

Journal of Translational Internal Medicine

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Coronary atherosclerosis is a chronic inflammatory disease that can lead to varying degrees of blood flow obstruction and a common pathophysiological basis of cardiovascular disease. Inflammatory factors run through the whole process of atherosclerotic lesions. Macrophages, T cells, and neutrophils play important roles in the process of atherosclerotic inflammation. Considering the evolutionary characteristics, atherosclerosis can be divided into different stages as early atherosclerotic plaque, plaque formation stage, and plaque rupture stage. In this paper, the changes in inflammatory cells at different stages of lesions and their related mechanisms are discussed, which can provide new insights from a clinical to bench perspective for atherosclerosis me chanism.

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Section: Plaque Rupture Stage: Inflammatory Cells and Vulnerable Plaquesmentioning

confidence: 99%