The Newest Member of the Family of Chloralose: Synthesis of <i>β</i>‐Ribochloralose and Some Derivatives

Ay, Kadir; Halay, Erkan

doi:10.1155/2013/748161

Cited by 3 publications

(2 citation statements)

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“…15). 57 In this synthesis azidofuranoses 98-100 were synthesized by three processes, firstly protection of corresponding monosaccharides with either trichloroethylidene (for ribose) or isopropylidene (for mannose and glucose), after that the addition of a leaving group and its exchange with sodium azide [58][59][60][61] and propargylated nucleobases 101-104 62 were synthesized by the propargylation of nucleobases (uracil, thymine, 5-fluorouracil, and adenine) with propargyl bromide in the presence of K2CO3 in DMF solvents at 50 ᵒC for 8-12 h.…”

Section: Synopen Review / Short Reviewmentioning

confidence: 99%

“…Halay and co-workers synthesized triazolylmethyl-linked nucleoside derivatives 105 – 116 by click cycloaddition reaction of azidofuranoses 98 – 100 with propargylated nucleobases 101 – 104 in the presence of CuSO 4 ·5H 2 O and sodium ascorbate in the solvent THF/ t -BuOH/H 2 O (3:1:1) at 50 °C for 3–6 h (Scheme 15 ). 57 In this synthesis, azidofuranoses 98 – 100 were synthesized by three processes, firstly protection of corresponding monosaccharides with either trichloroethylidene (for ribose) or isopropylidene (for mannose and glucose), after that the addition of a leaving group and its exchange with sodium azide 58 59 60 61 and propargylated nucleobases 101 – 104 62 were synthesized by the propargylation of nucleobases (uracil, thymine, 5-fluorouracil, and adenine) with propargyl bromide in the presence of K 2 CO 3 in DMF solvents at 50 °C for 8–12 h.…”

Section: Cuaac Click Chemistry Mediated Synthesis Of Triazole-based G...mentioning

confidence: 99%

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Recent Advances in the Synthesis of Bioactive Glycohybrids via Click-Chemistry

Singh

Tyagi

Mishra

et al. 2023

SynOpen

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Carbohydrates, traditionally known for their energy-providing role, have gained significant attention in drug discovery due to their diverse bioactivities and stereodiversity. However, pure carbohydrate molecules often exhibit limited bioactivity and suboptimal chemical and physical characteristics. To address these challenges, functional groups with bioactive scaffolds have been incorporated into carbohydrate to enhance their bioactivity and improve their overall properties. Among the various synthetic methods available, click chemistry has emerged as a powerful tool for the synthesis of carbohydrate-containing bioactive scaffolds, known as glycohybrids. Click chemistry offers several advantages, including high chemo- and regioselectivity, mild reaction conditions, easy purification and compatibility with multiple functional groups. In the present review, we have emphasized the recent advances and most pertinent research on the development of 1,2,3-triazole-containing glycohybrids using click reaction, their biological evaluations and the structure-activity relationship during 2017-2023. These newly synthesised glycohybrids could potentially be developed as new chemical entities (NCE) in pharmaceutical chemistry and may encourage the use of carbohydrates in drug discovery processes. 1 Introduction 2 CuAAC click chemistry mediated synthesis of triazole based glycohybrids and their biological activities 3 Conclusions and perspective

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