The NIH NeuroBioBank: creating opportunities for human brain research

Freund, Michelle; Taylor, Anna; Ng, Cathy; Little, A. Roger

doi:10.1016/b978-0-444-63639-3.00004-9

Cited by 15 publications

(11 citation statements)

References 28 publications

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“…preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in The copyright holder for this this version posted August 10, 2021. ; https://doi.org/10.1101/2021.08.10.21261758 doi: medRxiv preprint represented their wishes. Reiterating the recommendations from brain donation literature, the implementation of active outreach awareness campaigns and culturally relevant educational protocols is needed globally, not only to address the current decline in post-mortem donations but to ensure that families have a positive experience with the donation request [17,23,38,50,91,92].…”

Section: Discussionmentioning

confidence: 99%

“…Even if being surprised by the brain donation request was not associated with negative reactions in this study, all participants claimed they would prefer to know more about it before the request because the knowledge gap was considered an obstacle to processing information and reaching a decision that best represented their wishes. Reiterating the recommendations from brain donation literature, the implementation of active outreach awareness campaigns and culturally relevant educational protocols is needed globally, not only to address the current decline in post-mortem donations but to ensure that families have a positive experience with the donation request [17,23,38,50,91,92].…”

Section: Discussionmentioning

confidence: 99%

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“At that moment, understanding the donation is crucial to make a decision”:A qualitative study exploring the process of postmortem brain tissue donation after suicide

Padoan

Garcia

Crespo

et al. 2021

Preprint

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Background: The direct examination of postmortem brain tissue can provide valuable help in refining knowledge on the pathophysiology and genetics of neuropsychiatric disorders. Obtaining postmortem consent for the donation of brain tissue after death by suicide can be difficult, as families may be overwhelmed by a violent and unexpected death. Examining the process of brain donation can inform on how the request can best be conducted, examining the existing barriers and enhancing communication, to the benefit of proxy donors. Methods: This is a qualitative study, in which we employed in-depth interviews to investigate the donation process. Family members of decedents who were eligible for brain tissue donation were asked to consider the donation; irrespective of their decision, they were invited for an interview on the donation process at least 2 months after the suicide. Data collection and analyses were carried out according to a grounded theory framework, and collection, coding, and theorization occurred simultaneously. Findings: Forty-one people participated in this study, 32 family members who had consented to donation and 9 who refused it. Five key themes emerged from our data analysis: the context of the families of potential donors, the invitation to talk to the research team, the experience with the request protocol, the participants' assessment of the experience, and their participation in the study as an opportunity to heal. We arranged the main categories around 3 central stages of the experience described by participants: before the donation request, the request, and after the request. Conclusions: The participants indicated that a brain donation request that is respectful and tactful can be made without adding to the family distress brought on by suicide and is viewed in a highly positive lens in the months following the event. Having an adequate understanding of tissue donation for research was crucial for satisfactory decision-making. Meeting with the donation team was considered a chance to talk to mental health professionals about suicide. Pondering brain donation was seen as an opportunity to transform the meaning of the death and invest it with a modicum of solace for being able to contribute to research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“At that moment, understanding the donation is crucial to make a decision”:A qualitative study exploring the process of postmortem brain tissue donation after suicide

Padoan

Garcia

Crespo

et al. 2021

Preprint

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“…The NIH NeuroBioBank (NBB) networks six brain tissue repositories, with the largest one storing over 2000 brain samples, in order to facilitate the collection and redistribution of highquality brain tissues in the United States. [53] Despite the high level of relevance to human brain disorders, postmortem brain studies are limited in their ability to provide information on dynamic, temporal changes of disease progression. Furthermore, from the perspective of disease prevention or treatment, molecular and cellular changes may occur years prior to clinical presentation of symptoms of the decline in cognitive or motor skills [54] and researchers cannot control the genetic background or the external insults to the study objects.…”

Section: Human Postmortem Brain Tissuesmentioning

confidence: 99%

Section: Ex Vivo and 2d In Vitro Platforms To Study The Brainmentioning

confidence: 99%

Innovations in 3D Tissue Models of Human Brain Physiology and Diseases

Lovett

Nieland

Dingle

et al. 2020

Adv Funct Materials

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3D laboratory tissue cultures have emerged as an alternative to traditional 2D culture systems that do not recapitulate native cell behavior. The discrepancy between in vivo and in vitro tissue-cell-molecular responses impedes understanding of human physiology in general and creates roadblocks for the discovery of therapeutic solutions. Two parallel approaches have emerged for the design of 3D culture systems. The first is biomedical engineering methodology, including bioengineered materials, bioprinting, microfluidics, and bioreactors, used alone or in combination, to mimic the microenvironments of native tissues. The second approach is organoid technology, in which stem cells are exposed to chemical and/or biological cues to activate differentiation programs that are reminiscent of human (prenatal) development. This review article describes recent technological advances in engineering 3D cultures that more closely resemble the human brain. The contributions of in vitro 3D tissue culture systems to new insights in neurophysiology, neurological diseases, and regenerative medicine are highlighted. Perspectives on designing improved tissue models of the human brain are offered, focusing on an integrative approach merging biomedical engineering tools with organoid biology.

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“…To combine willed body donation for medical education and brain donation for research with the same donor, is an efficient opportunity to address both (education and research) needs. Although research groups have included post-mortem MRI in their studies, most notable in the case of patient H.M. (Augustinack et al, 2014), to our knowledge, none of the brain banks worldwide have high-field, whole-brain post-mortem in situ magnetic resonance imaging (MRI) data in combination with high quality brain tissue available for scientific research (Daniel and Lees, 1993; Freund et al, 2018; Friedman et al, 2017; Grinberg et al, 2007; Haroutunian and Pickett, 2007; Newcombe and Cuzner, 1993; Rademaker et al, 2018; Ramirez et al, 2018; Ravid and Swaab, 1993; Smith and Millar, 2018; Sutherland et al, 2016; Vonsattel et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls

Jonkman

Graaf

Bulk

et al. 2019

NeuroImage: Clinical

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Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience.

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The NIH NeuroBioBank: creating opportunities for human brain research

Cited by 15 publications

References 28 publications

“At that moment, understanding the donation is crucial to make a decision”:A qualitative study exploring the process of postmortem brain tissue donation after suicide

“At that moment, understanding the donation is crucial to make a decision”:A qualitative study exploring the process of postmortem brain tissue donation after suicide

Innovations in 3D Tissue Models of Human Brain Physiology and Diseases

Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls

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