The data of 12 water quality parameters have been daily monitored at the Nis station on the Nisava River during [2000][2001][2002][2003][2004]. The trend analysis was performed on monthly, seasonal and annual time series using the Mann-Kendall test, the Spearman's Rho test and the linear regression at the 5% significance level. The monthly results showed that significant trends were found only in pH, total hardness, Ca and SO 4 data. The results in seasonal series indicated that the significant trends were detected in pH, total hardness, Cl, Ca and SO 4 data. In annual series, the trends were insignificant at the 5% significance level.Podaci 12 parametara kvaliteta vode su prikupljani na mernoj stanici Niš tokom perioda 2000-2004. Analiza trenda je urađena za mesečne, sezonske i godišnje vremenske serije korišćenjem Mann-Kendall testa, Spearmanovog Rho testa i linearne regresije za 5% nivoa značajnosti. Mesečni rezultati pokazuju da značajni trendovi postoje samo za sledeće podatake: pH, ukupnu čvrstoću, Ca i SO 4 . Rezultati sezonskih serija ukazuju das u značajni trendovi detektovani za pH, ukupnu čvrstoću, Cl, Ca i SO 4 . Za godišnje serije, trendovi nisu značajni za 5% nivoa značajnosti.