The nitric oxide donating triamcinolone acetonide NCX 434 does not increase intraocular pressure and reduces endothelin-1 induced biochemical and functional changes in the rabbit eye

Abstract

NCX 434 attenuates ET-1 induced ischaemia/reperfusion damage without increasing IOP, probably due to NO release. If data are confirmed in other species and models, this compound could represent an interesting new therapeutic option for retinal and ONH diseases, including diabetic retinopathy.

Novel Insight of Histamine and Its Receptor Ligands in Glaucoma and Retina Neuroprotection

“…The effect of histamine H3R antagonists on the vascular performance at the posterior pole of the eye was evaluated through Doppler ultrasound studies of the ophthalmic The effect of histamine H 3 R antagonists on the vascular performance at the posterior pole of the eye was evaluated through Doppler ultrasound studies of the ophthalmic artery. In elevated IOP eyes, the Pourcelot Resistivity Index (RI) was significantly higher compared to physiological IOP eyes [61]; the treatment with histamine H 3 R antagonists significantly reduced Pourcelot RI, indicating a role of histamine in controlling the vascular tone at the ocular level. It is well known that vascular impairment in the eye is important in the pathogenesis of normotensive glaucoma.…”

“…artery. In elevated IOP eyes, the Pourcelot Resistivity Index (RI) was significantly higher compared to physiological IOP eyes [61]; the treatment with histamine H3R antagonists significantly reduced Pourcelot RI, indicating a role of histamine in controlling the vascular tone at the ocular level. It is well known that vascular impairment in the eye is important in the pathogenesis of normotensive glaucoma.…”

gem-Dinitroalkyl Benzenes: A Novel Class of IOP-Lowering Agents for the Treatment of Ocular Hypertension

“…It is known from the literature that nitrite displays an IOP-lowering ability after topical administration in a normotensive rabbit model. 11 In a high IOP context, a significant reduction in ocular blood flow in the retinic artery 28,29 and shear stress at the endothelial level both occur. These events are accompanied by cellular hypoxia, which increases the vasodilator potency of NO releasing compounds and aqueous humor drainage.…”