1997
DOI: 10.1038/ki.1997.257
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The nitric oxide donor nitroprusside intraperitoneally affects peritoneal permeability in CAPD

Abstract: Nitroprusside is a nitric oxide (NO) donor. To investigate effects of nitroprusside i.p. on peritoneal permeability and perfusion, standard peritoneal permeability analyses were performed. Ten stable CAPD patients were studied twice within one week with glucose based dialysate (1.36% Dianeal) with and without addition of nitroprusside 4.5 mg/liter. Mass transfer area coefficients (MTAC) of CO2 were calculated to estimate peritoneal blood flow. Nitrate, a stable metabolite of NO, and cGMP, a second messenger of… Show more

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Cited by 63 publications
(35 citation statements)
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“…Addition of the NO donor nitroprusside to the dialysate increases EPSA in rat models (23) and stable PD patients (24). An increased release of NO is also involved in the increased EPSA and the loss of UF that are observed during acute peritonitis (25).…”
Section: Discussionmentioning
confidence: 99%
“…Addition of the NO donor nitroprusside to the dialysate increases EPSA in rat models (23) and stable PD patients (24). An increased release of NO is also involved in the increased EPSA and the loss of UF that are observed during acute peritonitis (25).…”
Section: Discussionmentioning
confidence: 99%
“…With dissipation of the osmotic gradient with time as a result of glucose absorption, a subordinate vasodilation is preferentially maintained in the smaller intestinal premucosal A3, whereas the feed A1 at most restore their baseline diameter and blood flow, which explains the relatively lower PS for small solutes during the late phase of the dwell. In contrast, in peritoneal transport rate studies in humans, the addition of a clinical dose of sodium nitroprusside to a dialysis solution produced no effect on peritoneal fluid kinetics, a slight increase in MTAC for small solutes, but a great increase in macromolecular clearances (35). Similarly, in rabbits, a clinical dose of sodium nitroprusside exclusively enhanced peritoneal macromolecular clearance (36).…”
Section: Vascular Reactivitymentioning
confidence: 96%
“…Although one of the amino acids of this dialysate was L-arginine, a substrate for nitric oxide synthesis, the effects of the amino acid solution could not be attributed to nitric oxide synthesis. Intraperitoneal administration of the nitric oxide donor nitroprusside also caused changes in permeability characteristics [6]. These changes were accompanied by local generation of cyclic guanosine monophosphate, the second messenger of nitric oxide synthesis.…”
Section: Introductionmentioning
confidence: 96%