The Non-Haemostatic Response of Platelets to Stress: An Actor of the Inflammatory Environment on Regenerative Medicine?

Cognasse, Fabrice; Hamzeh‐Cognasse, Hind; Mismetti, Patrick; Thomas, Thierry; Eglin, David; Marotte, Hubert

doi:10.3389/fimmu.2021.741988

Cited by 9 publications

(9 citation statements)

References 15 publications

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“…The measurable characteristics of PRP (in comparison with whole blood/plasma measurements) are platelet count/folds of platelet concentration, levels of GFs, cytokines, chemokines, proinflammatory and anti-inflammatory factors, adhesion molecules, lysosomal enzymes, and extracellular vesicles. The PRP contains a diverse group of factors which collectively are responsible for the therapeutic outcomes [ 4 ] ( Figure 4 ). But there are no studies available which consider the broader picture.…”

Section: Discussionmentioning

confidence: 99%

“…This is due to the extensive nature of the parameters which need to be considered and the limitation of resources available for the process [ 2 ]. Different cell types and tissues have variable requirements of GFs or cytokines for their proliferation; also multiple of these factors can have overlapping functions in different cell types [ 4 ]. This highlights the need to consider the tissue specific requirements of the constituents in PRP/PRP products.…”

Section: Discussionmentioning

confidence: 99%

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Variability in Platelet-Rich Plasma Preparations Used in Regenerative Medicine: A Comparative Analysis

Tey

Haldankar

Joshi

et al. 2022

Stem Cells International

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Background. Platelet-rich plasma (PRP) and its derivatives are used in several aesthetic, dental, and musculoskeletal procedures. Their efficacy is primarily due to the release of various growth factors (GF), interleukins, cytokines, and white blood cells. However, the PRP preparation methods are highly variable, and studies lack consistency in reporting complete procedures to prepare PRP and characterize PRP and its derivatives. Also, all the tissue-specific (in vivo and in vitro) interactions and functional properties of the various derivatives/factors of the PRP have not been taken into consideration by any study so far. This creates a potential space for further standardization of the PRP preparation methods and customization of PRP/PRP derivatives targeted at tissue-specific/pathology specific requirements that would enable efficacious and widely acceptable usage of PRP as main therapy, rather than being used as adjuvant therapy. The main objective of our study was to investigate the variability in PRP preparation methods and to analyze their efficacy and reliability. Method. This study considered articles published in the last 5 years, highlighting the variability in their PRP preparation methods and characterization of PRP. Following the PRISMA protocol, we selected 13 articles for the study. The selected articles were assessed using NHLBI quality assessment tool. Results. We noted differences in (1) approaches to producing PRP, (2) extent of characterization of PRP, (3) small scale and large-scale preparation methods, (4) in vitro and in vivo studies. Conclusion. We identified two studies describing the procedures which are simple, reproducible, economical, provide a good yield of platelets, and therefore can be considered methods for further tissue-specific and pathology-specific standardizations of PRP and its derivatives. We recommend further randomized studies to understand the full therapeutic potential of the constituents of PRP and its derivatives.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Variability in Platelet-Rich Plasma Preparations Used in Regenerative Medicine: A Comparative Analysis

Tey

Haldankar

Joshi

et al. 2022

Stem Cells International

View full text Add to dashboard Cite

show abstract

“…The measurable characteristics of PRP (In comparison with whole blood/plasma measurements) are platelet count/folds of platelet concentration, levels of GF's, cytokines, chemokines, proin ammatory and anti-in ammatory factors, adhesion molecules, lysosomal enzymes, extracellular vesicles. The PRP contains a diverse group of factors which collectively are responsible for the therapeutic outcomes [7]. But there are no studies available which consider the broader picture.…”

Section: Addressing the Variabilitymentioning

confidence: 99%

“…This is due to the extensive nature of the parameters which need to be considered and the limitation of resources available for the process [19]. Different cell types and tissues have variable requirements of growth factors or cytokines for their proliferation, also multiple of these factors can have overlapping functions in different cell types [7]. This highlights the need to consider the tissue speci c requirements of the constituents in PRP /PRP products.…”

Section: Addressing the Variabilitymentioning

confidence: 99%

“…The therapeutic effect of PRP is attributed to its ability to release different types of growth factors, cytokines, and interferons. They promote angiogenesis, broblast proliferation, epithelial cell proliferation, and healing at the site of the wound when used as an adjunct to standard wound care practice [3,7,18]. But unlike drugs/pharmaceuticals where the quality of a compound is ensured by a standardized mechanized procedure, the biologics eld is in its adolescence.…”

Section: Introductionmentioning

confidence: 99%

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Variability in Platelet-Rich Plasma Preparations Used in Regenerative Medicine: A Systematic Review.

Tey

Joshi

Haldankar

et al. 2022

Preprint

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Background Platelet-rich plasma (PRP) and its derivatives are used in several aesthetic, dental, and musculoskeletal procedures. Their efficacy is primarily due to the release of various growth factors (GF), interleukins, cytokines, and white blood cells. However, the PRP preparation methods are highly variable, and studies lack consistency in reporting complete procedures to prepare PRP and characterize PRP and its derivatives. Also, all the tissue-specific (in vivo and in vitro) interactions and functional properties of the various derivatives/factors of the PRP have not been taken into consideration by any study so far. This creates a potential space for further standardization of the PRP preparation methods and customization of PRP/PRP derivatives targeted at tissue-specific/pathology specific requirements that would enable efficacious and widely acceptable usage of PRP as main therapy, rather than being used as adjuvant therapy. The main objective of our study was to investigate the variability in PRP preparation methods and to analyze their efficacy and reliability. Method This study considered articles published in the last 5 years, highlighting the variability in their PRP preparation methods and characterization of PRP. Following the PRISMA protocol, we selected 12 articles for the study. The selected articles were assessed using NHLBI quality assessment tool. Results We noted differences in 1) approaches in producing PRP, 2) extent of characterization of PRP, 3) small scale and large-scale preparation methods, 4) in vitro and in vivo studies. Conclusion We identified two studies describing the procedures which are simple, reproducible, economical, provide a good yield of platelets, and therefore can be considered methods for further tissue-specific and pathology-specific standardizations of PRP and its derivatives. We recommend further randomized studies to understand the full therapeutic potential of the constituents of PRP and its derivatives.

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Platelet transfusion in adults: An update

Garraud

Hamzeh‐Cognasse²,

Chalayer³

et al. 2023

Transfusion Clinique et Biologique

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The Non-Haemostatic Response of Platelets to Stress: An Actor of the Inflammatory Environment on Regenerative Medicine?

Cited by 9 publications

References 15 publications

Variability in Platelet-Rich Plasma Preparations Used in Regenerative Medicine: A Comparative Analysis

Variability in Platelet-Rich Plasma Preparations Used in Regenerative Medicine: A Comparative Analysis

Variability in Platelet-Rich Plasma Preparations Used in Regenerative Medicine: A Systematic Review.

Platelet transfusion in adults: An update

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