The noncognitive features of dementia

Allen, N.S.; Burns, Alistair

doi:10.1017/s0959259800003981

Cited by 39 publications

(31 citation statements)

References 127 publications

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“…The present study confirmed that activity disturbances were the most frequently occurring BPSD in AD patients (Allen and Burns, 1995). Although most studies reported that aggression occurred in 20-30% of AD patients (Allen and Burns, 1995), we found frequencies of 75% by means of the Behave-AD aggressiveness cluster score.…”

Section: Behavioural Profiles Of Different Disease Groupssupporting

confidence: 88%

Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study

Engelborghs

Maertens

Nagels

et al. 2005

Int. J. Geriat. Psychiatry

108

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Behavioural assessment may help differentiating between different forms of dementia, further stressing the need for the development of new and more sensitive behavioural assessment scales. By means of the MFS, frontal lobe involvement was frequently observed in DLB. As 70% of FTD patients displayed apathy, prevalence was about two times higher compared to the other disease groups, meanwhile indicating that apathy is frequently observed in dementia, irrespective of its etiology.

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Section: Behavioural Profiles Of Different Disease Groupssupporting

confidence: 88%

Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study

Engelborghs

Maertens

Nagels

et al. 2005

Int. J. Geriat. Psychiatry

108

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show abstract

“…Thus, the prevalence of non-cognitive symptoms, rates of cognitive decline and average duration of illness was, in general, in keeping with those found in other studies (Allen and Burns, 1995). Apart from age of onset, where a positive family history of dementia was associated with an earlier age of onset no signi®-cant differences were found in clinical phenotype between familial and sporadic cases.…”

Section: Discussionsupporting

confidence: 88%

The clinical phenotype of familial and sporadic late onset Alzheimer's disease

Holmes¹,

Lovestone²

2002

Int J Geriat Psychiatry

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“…Depression is believed to be a risk factor for the onset of Alzheimer's disease (Green et al, 2003;Chen et al, 1999;Kokmen et al, 1991;Kral and Emery, 1989). Affective disorders are often comorbid with neurodegenerative disorders that are associated with dementia (Allen and Burns, 1995;Schreinzer et al, 2004;Lauterbauch et al, 2004). Affective symptoms are frequently part of the initial presentation in neurodegenerative diseases (Ishihara and Brayne, 2006;Kessing and Anderson, 2004), and, in some cases, may be the dominant presenting symptoms (Ballard et al, 2002).…”

Section: Possible Relevance Of 5-htt Axon Degeneration To Symptoms Ofmentioning

confidence: 99%

Dystrophic serotonergic axons in neurodegenerative diseases

Azmitia¹,

Nixon²

2008

Brain Research

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Neurodegenerative diseases such as Parkinson's disease (PD), frontal lobe dementia (FLD) and Diffuse Lewy-Body dementia (DLBD) have diverse neuropathologic features. Here we report that serotonin fibers are dystrophic in the brains of individuals with these three diseases. In neuropathologically normal (control) brains (n=3), serotonin axons immunoreactive (IR) with antibodies against the serotonin transporter (5-HTT) protein were widely distributed in cortex (entorhinal and dorsolateral prefrontal), hippocampus and rostral brainstem. 5-HTT-IR fibers of passage appeared thick, smooth, and un-branched in medial forebrain bundle, medial lemniscus and cortex white matter. The terminal branches were fine, highly branched and varicose in substantia nigra, hippocampus and cortical gray matter. In the diseased brains, however, 5-HTT-IR fibers in the forebrain were reduced in number and were frequently bulbous, splayed, tightly clustered and enlarged. Morphometric analysis revealed significant differences in the size distribution of the 5-HTT-IR profiles in dorsolateral prefrontal area between neurodegenerative diseases and controls. Our observations provide direct morphologic evidence for degeneration of human serotonergic axons in the brains of patients with neurodegenerative diseases despite the limited size (n=3 slices for each region (3) from each brain (4), total slices was n=36) and lack of extensive clinical characterization of the analyzed cohort. This is the first report of dystrophic 5-HTT-IR axons in postmortem human tissue

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The noncognitive features of dementia

Cited by 39 publications

References 127 publications

Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study

Neuropsychiatric symptoms of dementia: cross-sectional analysis from a prospective, longitudinal Belgian study

The clinical phenotype of familial and sporadic late onset Alzheimer's disease

Dystrophic serotonergic axons in neurodegenerative diseases

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