“…Hanna et al, 53 in an analysis of more than 8,000 patients in the Trauma Quality Improvement database, reported that LTOWB was independently associated with reduced 24-hour mortality, in-hospital mortality, and major complications in adults with traumatic bleeding. At this time, the use of cold-stored whole blood is considered a best practice by the US military, in adult trauma centers in the United States, and internationally 43,54–56 . The benefits and risks of LTOWB compared with component therapy are summarized in Table 1 45,50,51,53,57,58 …”