The Notch signaling pathway regulates macrophage polarization in liver diseases

Chen, Wenyan; Liu, Yining; Chen, Jing; Ma, Yemei; Song, Yawen; Cen, Yanli; You, Mingdan; Yang, Guosheng

doi:10.1016/j.intimp.2021.107938

Cited by 58 publications

(30 citation statements)

References 55 publications

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“…The Notch signaling pathway is associated with inflammation and immunity and can contribute to the occurrence and development of inflammation [ 27 , 28 ]. The change in the Notch signaling pathway can cause macrophages to be polarized to the M2 subtype, leading to an anti-inflammatory response [ 29 ]. Despite the overall manifestation of the Notch signaling pathway being downregulated (11/48) with 2 upregulated mRNAs and 9 downregulated mRNAs in this study, notch4 and presenilin-2 were found to be upregulated.…”

Section: Discussionmentioning

confidence: 99%

Toxocara canis Infection Alters mRNA Expression Profiles of Peripheral Blood Mononuclear Cells in Beagle Dogs at the Lung Infection Period

Cai

Zou

et al. 2022

Animals

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Toxocara canis is a neglected zoonotic roundworm distributed all over the world, causing toxocariasis in humans and animals. However, so far, the immune mechanism of T. canis infection in definitive hosts remains to be clarified. In this study, the transcriptional alterations of Beagle dogs’ peripheral blood mononuclear cells (PBMCs) induced by T. canis infection during the lung infection period were analyzed using RNA-seq technology. A total of 2142 differentially expressed genes were identified, with 1066 upregulated genes and 1076 downregulated genes. Many differentially expressed genes participated in the biological process of intracellular signal transduction, as well as the immune- or inflammation-related KEGG signaling pathway, such as the Notch signaling pathway, Toll-like receptor signaling pathway, and NF-kappa B signaling pathway, through KEGG enrichment analysis. This study indicated that T. canis infection could suppress the biological function of Beagle dogs’ PMBCs and provided basic data to further clarify the interaction mechanism between T. canis and host immune cells.

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Section: Discussionmentioning

confidence: 99%

Toxocara canis Infection Alters mRNA Expression Profiles of Peripheral Blood Mononuclear Cells in Beagle Dogs at the Lung Infection Period

Cai

Zou

et al. 2022

Animals

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“…However, a relevant study identi ed DEGs between high-and low-in ltrating M1 macrophages as predictors of HCC prognosis [30]. The activation of Notch signaling in HCC can mediate the differentiation of macrophages into M1 macrophages, promoting in ammation and antitumor activity [31]. In this study, signi cantly increased in ltration of M1 macrophages was observed in cluster 1, indicating the activation of the in ammatory response and antitumor activity against HCC, which is why patients in cluster 1 showed better clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Identification of molecular subtypes and prognostic signatures based on transient receptor potential channel-related genes to predict the prognostic risk of hepatocellular carcinoma

Cai

Liu

et al. 2022

Preprint

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Objective: Abnormal transient receptor potential (TRP) channel function interferes with intracellular calcium-based signaling and causes malignant phenotypes. However, effects of TRP channel-related genes on hepatocellular carcinoma (HCC) remain unknown. This study aimed to identify HCC molecular subtypes and prognostic signatures based on TRP channel-related genes to predict its prognostic risks. Methods: With the expression data of TRP channel-related genes, unsupervised hierarchical clustering was applied to identify HCC molecular subtypes, followed by comparisons of clinical and immune microenvironment characteristics between the resulting subtypes. After screening differentially expressed genes (DEGs) among subtypes, prognostic signatures were identified to construct risk score-based prognostic and nomogram models and predict HCC survival. Finally, tumor drug sensitivities were predicted and compared between risk groups. Results: Sixteen TRP channel-related genes that were differentially expressed between HCC and normal tissues were used to identify two subtypes, of which cluster 1 had higher TRP scores, better survival status, and lower levels of clinical malignancy. Immune-related analyses also revealed higher infiltrations of M1 macrophages and immune and stromal scores in cluster 1 compared with cluster 2. After screening DEGs between subtypes, six prognostic signatures were identified to construct prognostic and nomogram models. The potential of these models for assessing HCC prognostic risks was further validated. Furthermore, cluster 1 was more distributed in the low-risk group with higher drug sensitivities. Conclusion: Two HCC subtypes were identified, among which cluster 1 was associated with a favorable prognosis. Prognostic signatures related to TRP channel genes and molecular subtypes can predict HCC prognostic risks.

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“…The Notch signaling pathway can promote macrophage differentiation into the M1 phenotype and contribute to the expression of proinflammatory cytokines (Castro et al, 2021; (iv) IL-4 or IL-13 binds to its corresponding receptor and triggers the activation of STAT3 or STAT6, respectively, inducing the transcription of anti-inflammatory cytokines and skewing macrophages to the anti-inflammatory M2 phenotype. Chen et al, 2021). Notch proteins are proteolytically cleaved by furin-like proteinase at cleavage site 1 (S1) and processed into the mature form.…”

Section: Notch Signaling Pathwaymentioning

confidence: 99%

Modulation of Macrophage Polarization by Viruses: Turning Off/On Host Antiviral Responses

et al. 2022

Front. Microbiol.

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Macrophages are professional antigen-presenting cells and serve as the first line of defense against invading pathogens. Macrophages are polarized toward the proinflammatory classical (M1) or anti-inflammatory alternative (M2) phenotype upon viral infections. M1-polarized macrophages exert critical roles in antiviral responses via different mechanisms. Within the long competitive history between viruses and hosts, viruses have evolved various immune evasion strategies, inhibiting macrophage acquisition of an antiviral phenotype, impairing the antiviral responses of activated macrophages, and/or exploiting macrophage phenotypes for efficient replication. This review focuses on the sophisticated regulation of macrophage polarization utilized by viruses and is expected to provide systematic insights into the regulatory mechanisms of macrophage polarization by viruses and further facilitate the design of therapeutic targets for antivirals.

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The Notch signaling pathway regulates macrophage polarization in liver diseases

Cited by 58 publications

References 55 publications

Toxocara canis Infection Alters mRNA Expression Profiles of Peripheral Blood Mononuclear Cells in Beagle Dogs at the Lung Infection Period

Toxocara canis Infection Alters mRNA Expression Profiles of Peripheral Blood Mononuclear Cells in Beagle Dogs at the Lung Infection Period

Identification of molecular subtypes and prognostic signatures based on transient receptor potential channel-related genes to predict the prognostic risk of hepatocellular carcinoma

Modulation of Macrophage Polarization by Viruses: Turning Off/On Host Antiviral Responses

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