The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation

Arias, Hugo R.; Rudin, Deborah; Hines, Dustin J.; Contreras, April; Gulsevin, Alican; Manetti, Dina; Anouar, Youssef; De Deurwaerdere, Philippe; Meiler, Jens; Romanelli, Maria Novella; Liechti, Matthias E.; Chagraoui, Abdeslam

doi:10.1016/j.ejphar.2024.176329

European Journal of Pharmacology

2024

DOI: 10.1016/j.ejphar.2024.176329

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The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation

Hugo R. Arias,

Deborah Rudin,

Dustin J. Hines

et al.

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Cited by 3 publications

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The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation

Cited by 3 publications

References 62 publications

Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation

Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation

Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic Cortex

The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission

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