2007
DOI: 10.1038/nrg2122
|View full text |Cite
|
Sign up to set email alerts
|

The nuclear envelope and transcriptional control

Abstract: Cells have evolved sophisticated multi-protein complexes that can regulate gene activity at various steps of the transcription process. Recent advances highlight the role of nuclear positioning in the control of gene expression and have put nuclear envelope components at centre stage. On the inner face of the nuclear envelope, active genes localize to nuclear-pore structures whereas silent chromatin localizes to non-pore sites. Nuclear-pore components seem to not only recruit the RNA-processing and RNA-export … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

13
375
0

Year Published

2008
2008
2023
2023

Publication Types

Select...
4
4

Relationship

1
7

Authors

Journals

citations
Cited by 410 publications
(394 citation statements)
references
References 93 publications
13
375
0
Order By: Relevance
“…A recent study of the amounts of lamin A/C in various hematologic malignancies provided evidence for epigenetic silencing at the lamin A/C promoter region by CpG island methylation in a subset of leukemias and lymphomas. [48] There is increasing evidence that gene silencing occurs at the nuclear envelope (see recent reviews [10,13]) promoted, in part, by integral proteins of the nuclear envelope. Thus, it is tempting to speculate that increased LBR content may augment repression of the lamin A/C genes and/or facilitate sequestration of the epigenetically repressed lamin A/C genes to the peripheral nuclear heterochromatin.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…A recent study of the amounts of lamin A/C in various hematologic malignancies provided evidence for epigenetic silencing at the lamin A/C promoter region by CpG island methylation in a subset of leukemias and lymphomas. [48] There is increasing evidence that gene silencing occurs at the nuclear envelope (see recent reviews [10,13]) promoted, in part, by integral proteins of the nuclear envelope. Thus, it is tempting to speculate that increased LBR content may augment repression of the lamin A/C genes and/or facilitate sequestration of the epigenetically repressed lamin A/C genes to the peripheral nuclear heterochromatin.…”
Section: Discussionmentioning
confidence: 99%
“…The cell lines employed in the present study, derived from LBR-deficient bone marrow cells, are suitable materials for analysis of the importance of LBR to the distribution of interphase nuclear chromosome territories [56] and to the dynamics of chromatin mobility during in vitro granulopoiesis. [13,57] Confocal immunostaining of undifferentiated and granulocytic EPRO cells with anti-LAP2β and anti-C-Nap1. Genotypes: wildtype, +/+; heterozygous ichthyosis, +/ic; homozygous ichthyosis, ic/ ic.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Interphase chromosomes are highly dynamic, with active chromatin in an open conformation and undergoing continual exchange of protein components , Phair & Misteli 2000. Chromosomal loci are known to be mobile (Marshall et al 1997, Bystricky et al 2004, Levi et al 2005, and recently it has been shown that gene positioning affects gene expression (Brickner & Walter 2004, Ahmed & Brickner 2007, Akhtar & Gasser 2007, Lanctot et al 2007.…”
Section: Introductionmentioning
confidence: 99%
“…Recent studies suggest that the nucleus contains spatially and functionally distinct subcompartments, which in some cases depend on elements of nuclear architecture, such as the nuclear lamina or nuclear pores. Such structures presumably function as scaffolds for different chromosomal activities by recruiting either substrates, enzymes or both [1].…”
Section: Introductionmentioning
confidence: 99%