1999
DOI: 10.1074/jbc.274.45.32091
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The Nuclear Factor-κB Engages CBP/p300 and Histone Acetyltransferase Activity for Transcriptional Activation of the Interleukin-6 Gene Promoter

Abstract: Expression of the pleiotropic cytokine interleukin (IL)-6 can be stimulated by the proinflammatory cytokine tumor necrosis factor (TNF) and the microbial alkaloid staurosporine (STS). In this report, the transcriptional mechanisms were thoroughly investigated. Whereas transcription factors binding to the activator protein-1-, cAMP-responsive element-, and CAAT enhancer-binding protein-responsive sequences are necessary for gene activation by STS, nuclear factor (NF)-B alone is responsible and sufficient for in… Show more

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Cited by 338 publications
(267 citation statements)
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“…Specifically TNF␣ has been shown to up-regulate PLAA and CASP6 (51,52), both of which increased after IR in the wild type but not in the mutant. Decreased TNF␣ activity in p53 K317R thymocytes is also consistent with the observed lack of change in WARS, TCF7, and ETFDH protein levels after IR; all of these proteins are indirectly regulated by TNF␣ (53)(54)(55)(56)(57)(58). Finally TNF␣ has been shown to induce the expression of TGF␤1 (59), which has been shown to increase the expression of FABP5 and SSRP1 (60,61), two additional proteins that exhibit the same pattern.…”
Section: Discussionsupporting
confidence: 62%
“…Specifically TNF␣ has been shown to up-regulate PLAA and CASP6 (51,52), both of which increased after IR in the wild type but not in the mutant. Decreased TNF␣ activity in p53 K317R thymocytes is also consistent with the observed lack of change in WARS, TCF7, and ETFDH protein levels after IR; all of these proteins are indirectly regulated by TNF␣ (53)(54)(55)(56)(57)(58). Finally TNF␣ has been shown to induce the expression of TGF␤1 (59), which has been shown to increase the expression of FABP5 and SSRP1 (60,61), two additional proteins that exhibit the same pattern.…”
Section: Discussionsupporting
confidence: 62%
“…The IL-6 gene promoter contains binding sites for other transcription factors than NFkB, including AP-1, MRE and NF-IL6 transcription factors. [36][37][38][39] Both AP-1 and NF-IL6 have been shown to be involved in the regulation of IL-1b-induced IL-6 expression. 36,37,40 However, NFkB has been considered to be the predominant transcription factor regulating the IL-6 gene in response to inflammatory stimuli.…”
Section: Discussionmentioning
confidence: 99%
“…This insight initiated a new wave of pharmacological research directed toward the development of so-called dissociated ligands, favoring only GR-mediated transrepression of NF-B-or AP-1-driven gene expression (35)(36)(37)(38). Surprisingly, not all steroidal ligands that had dissociated properties in vitro also displayed these characteristics in vivo, especially with regard to the side-effect profile (35).…”
Section: Discussionmentioning
confidence: 99%