The pentaquark P + c (4450) recently discovered by LHCb has been interpreted as a bound state of Ψ(2S) and nucleon. The charmonium-nucleon interaction which provides the binding mechanism is given, in the heavy quark limit, in terms of charmonium chromoelectric polarizabilities and densities of the nucleon energy-momentum tensor (EMT). In this work we show in model-independent way, by exploring general properties of the effective interaction, that Ψ(2S) can form bound states with nucleon and ∆. Using the Skyrme model to evaluate the effective interaction in the large-Nc limit and estimate 1/Nc corrections, we confirm the results from prior work which were based on a different effective model (chiral quark soliton model). This shows that the interpretation of P + c (4450) is remarkably robust and weakly dependent on the details of the effective theories for the nucleon EMT. We explore the formalism further and present robust predictions of isospin pentaquarks with hidden charm can be observed.