The nucleotide sequence of Saccharomyces cerevisiae chromosome XII

Johnston, M.; Hillier, L.; Riles, L.; Albermann, K.; André, Brunó; Ansorge, W.; Benes, V.; Brückner, M.; Delius, H.; Dubois, E.; Düsterhöft, Andreas; Entian, K.-D.; Floeth, M.; Goffeau, André; Hebling, U.; Heumann, K.; Heuss-Neitzel, D.; Hilbert, Helmut; Hilger, F.; Kleine, K.; Kötter., P.; Louis, E. J.; Messenguy, F.; Mewes, H. W.; Miosga, T.; Möstl, D.; Müller-Auer, S.; Nentwich, U.; Obermaier, B.; Piravandi, E.; Pohl, T. M.; Portetelle, D.; Purnelle, B.; Rechmann, S.; Rieger, M.; Rinke, M.; Rose, M.; Scharfe, M.; Scherens, B.; Scholler, Patrik; Schwager, C.; Schwarz, S.; Underwood, A. P.; Urrestarazu, L. A.; Vandenbol, M.; Verhasselt, P.; Vierendeels, F.; Voet, M; Volckaert, G.; Voss, H.; Wambutt, R.; Wedler, E.; Wedler, H.; Zimmermann, F. K.; Zollner, A.; Hani, J.; Hoheisel, Jörg D.

doi:10.1038/387s087

Cited by 86 publications

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“…Recently, the complete genome of Saccharomyces cerevisiae was analyzed by several groups (Oliver et al 1992;Dojon et al 1994Dojon et al , 1997Feldman et al 1994;Johnston et al 1994Johnston et al , 1997Bussey et al 1995Bussey et al , 1997Murakami et al 1995;Galibert et al 1996;Goffeau et al 1996;Bowman et al 1997;Churcher et al 1997;Dietrich et al 1997;Jacq et Philippsen et al 1997;Tettelin et al 1997). We used their data from GenomeNet (http://www.genome.ad.jp) and analyzed them with a personal computer.…”

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confidence: 99%

Gene assembly consisting of small units with similar amino acid composition in the Saccharomyces cerevisiae genome

Sorimachi

Okayasu

2003

Mycoscience

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Amino acid compositions of all genes in Saccharomyces cerevisiae were determined using a computer analysis of the complete genome. The amino acid composition of an assembly of several genes or a single gene consisted of 3000-7000 amino acid residues forming a certain pattern of amino acid composition. This rule was independent not only of the gene size, but also of the gene position. Thus, the small units, consisting of 3000-7000 amino acid residues, showed a similar amino acid composition, and they formed all the genes in the complete genome.

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confidence: 99%

Gene assembly consisting of small units with similar amino acid composition in the Saccharomyces cerevisiae genome

Sorimachi

Okayasu

2003

Mycoscience

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“…RDN5 genes are the sole representatives of Type 1 promoters. They are present in 100-200 copies alternating with repeats of RDN37, the gene for the 35S rRNA, on chromosome XII (Johnston et al 1997).…”

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confidence: 99%

Retrotransposon profiling of RNA polymerase III initiation sites

Qi¹,

Daily²,

Nguyen³

et al. 2012

Genome Res.

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Although retroviruses are relatively promiscuous in choice of integration sites, retrotransposons can display marked integration specificity. In yeast and slime mold, some retrotransposons are associated with tRNA genes (tDNAs). In the Saccharomyces cerevisiae genome, the long terminal repeat retrotransposon Ty3 is found at RNA polymerase III (Pol III) transcription start sites of tDNAs. Ty1, 2, and 4 elements also cluster in the upstream regions of these genes. To determine the extent to which other Pol III-transcribed genes serve as genomic targets for Ty3, a set of 10,000 Ty3 genomic retrotranspositions were mapped using high-throughput DNA sequencing. Integrations occurred at all known tDNAs, two tDNA relics (iYGR033c and ZOD1), and six non-tDNA, Pol III-transcribed types of genes (RDN5, SNR6, SNR52, RPR1, RNA170, and SCR1). Previous work in vitro demonstrated that the Pol III transcription factor (TF) IIIB is important for Ty3 targeting. However, seven loci that bind the TFIIIB loader, TFIIIC, were not targeted, underscoring the unexplained absence of TFIIIB at those sites. Ty3 integrations also occurred in two open reading frames not previously associated with Pol III transcription, suggesting the existence of a small number of additional sites in the yeast genome that interact with Pol III transcription complexes.

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“…Immediately downstream of the ScRED1 gene is the RPS28B gene, which encodes a ribosomal protein (Johnston et al 1997). This same gene is found downstream of the KlRED1 gene (unpublished data).…”

Section: The K Lactis Red1 Transcript Is Splicedmentioning

confidence: 90%

Cloning and characterization of the Kluyveromyces lactis homologs of the Saccharomyces cerevisiae RED1 and HOP1 genes

Smith

2000

Chromosoma

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The synaptonemal complex (SC) is a meiosis-specific proteinaceous structure that holds homologous chromosomes close together along their length during the pachytene stage of meiotic prophase. The SC is observed in sexually reproducing fungi, plants and animals and is highly conserved at the cytological level. Despite this striking conservation of structure, however, the known protein components of the SC do not appear to be highly conserved across species. In Saccharomyces cerevisiae, the products of the RED1 and HOP1 genes are associated with the lateral elements of the SC. Using a functional complementation strategy, we have isolated homologs of these genes from the related yeast, Kluyveromyces lactis. The predicted K. lactis Red1 protein is 26% identical to the S. cerevisiae Red1 protein, and the K. lactis Hop1 protein is 40% identical to the S. cerevisiae Hop1 protein. The K. lactis RED1 gene fully complements the S. cerevisiae red1 mutant, both when overexpressed and when present in two copies in a diploid. However, the K. lactis HOP1 gene complements a hop1 mutant poorly when overproduced and not at all when present in two copies in a diploid. Unlike the S. cerevisiae RED1 gene, the K. lactis RED1 contains an intron; the transcript of the K. lactis gene is efficiently spliced during meiosis in S. cerevisiae.

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The nucleotide sequence of Saccharomyces cerevisiae chromosome XII

Cited by 86 publications

References 0 publications

Gene assembly consisting of small units with similar amino acid composition in the Saccharomyces cerevisiae genome

Gene assembly consisting of small units with similar amino acid composition in the Saccharomyces cerevisiae genome

Retrotransposon profiling of RNA polymerase III initiation sites

Cloning and characterization of the Kluyveromyces lactis homologs of the Saccharomyces cerevisiae RED1 and HOP1 genes

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