The numerical and experimental study of photon diffusion inside biological tissue using boundary integral method

Ansari, Mohammad Ali; Alikhani, Saeid; Mohajerani, Ezeddin; Massudi, Reza

doi:10.1016/j.optcom.2011.10.096

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…The reduced scattering and absorption coefficients of this layer at wavelength of 490 nm was 54 cm −1 and 0.003 cm −1 , respectively (based on methods presented in Refs. [36][37][38] ). The top layer is a mouse ear (2-month old, 20 g) with an average thickness of 250 μm.…”

Section: Phantom Fabricationmentioning

confidence: 99%

In vivo detection of human cutaneous beta‐carotene using computational optical clearing

Morovati

Ansari

Tuchin

2020

Journal of Biophotonics

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The content of dermal beta‐carotene can be a good indicator showing the body health. Because, it is involved in production of vitamin A maintaining healthy skin and mucous membranes. Also, it reduces the risk of cardiovascular diseases and its antioxidant capacity prevents the formation of cancerous cells. In this work, we use Raman spectroscopy and a low‐cost diffuse reflectance spectroscopy (DRS) to detect the dermal beta‐carotene spectra. We apply computational optical clearing (OC) method to in vivo evaluation the concentration of this chromophore. The results show that Raman spectroscopy is a good tool for in vitro detection of carotenoids but is not able to clearly discriminate the individual carotenoids in skin tissue in vivo. The results also show that using OC enhances the ability of low‐cost diffuse reflection spectroscopy for in vivo detection of dermal beta‐carotene in humans. This method can be used as a low‐cost and portable device to screening the concentration of chromophores such as melanin and carotenoid molecules for oncological studies.

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Section: Phantom Fabricationmentioning

confidence: 99%

In vivo detection of human cutaneous beta‐carotene using computational optical clearing

Morovati

Ansari

Tuchin

2020

Journal of Biophotonics

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“…This is unfortunate because there are many situations, such as particle combustion, laser machining, and even runaway device failure, where extremely high temper atures are reached, and traditional heat transfer models fail completely. It is noted that the term 'photon diffusion' is often used to describe light scattering in biological tissues [9][10][11] and also studied to analyze the nonradiative energy transfer (i.e. Förster resonance energy transfer) in donor-acceptor flu orophore molecules [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Photon diffusion in microscale solids

Das

Brown

Mah³

et al. 2019

J. Phys.: Condens. Matter

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This paper presents a theoretical and experimental investigation of photon diffusion in highly absorbing microscale graphite. A Nd:YAG continuous wave laser is used to heat the graphite samples with thicknesses of 40 μm and 100 μm. Optical intensities of 10 kW cm−2 and 20 kW cm−2 are used in the laser heating. The graphite samples are heated to temperatures of thousands of kelvins within milliseconds, which are recorded by a 2-color, high speed pyrometer. To compare the observed temperatures, differential equation of heat conduction is solved across the samples with proper initial and boundary conditions. In addition to lattice vibrations, photon diffusion is incorporated in the analytical model of thermal conductivity for solving the heat equation. The numerical simulations showed close matching between experiment and theory only when including the photon diffusion equations and existing material properties data found in the previously published works with no fitting constants. The results indicate that the commonly-overlooked mechanism of photon diffusion dominates the heat transfer of many microscale structures near their evaporation temperatures. In addition, the treatment explains the discrepancies between thermal conductivity measurements and theory that were previously described in the scientific literature.

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“…Optical imaging is a rapidly emerging method for a wide range of biomedical, medical and material investigations [1][2][3]. After invention of laser, this imaging has been introduced as blossoming technique for biomedical imaging.…”

Section: Introductionmentioning

confidence: 99%

“…In 2009, we have shown that diffuse equation can be solved by green function based boundary integral method (BIM). In this paper, the accuracy and precision of this numerical solution was compared with Monte Carlo and finite difference method [1,9].…”

Section: Introductionmentioning

confidence: 99%