2015
DOI: 10.1097/ta.0000000000000597
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The obesity factor in critical illness

Abstract: T he prevalence of obesity has increased starkly during the last decades, and this trend includes every age, sex, race and socioeconomic group. 1,2 According to the most recent epidemiologic data, 1,2 approximately two thirds of the US population are either overweight or obese, of whom approximately 30% are obese and more than 5% are morbidly obese. Although some reports suggest that the trend of obesity may have begun to stabilize within some segments of the US population, 3 other studies project that obesity… Show more

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Cited by 15 publications
(5 citation statements)
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“…In our cohort, 24% of the critically ill medical patients were obese or morbidly obese, as defined by a BMI above 30 kg/m 2 . This is in line with observations in the United States, where at least 25% of adult ICU patients are overweight, obese, or morbidly obese [ 30 , 31 ]. Interestingly, we did not find dysregulated visfatin levels between ICU patients with or without obesity, supporting that circulating visfatin levels in critical illness are primarily attributable to the extent of inflammation and not adiposity itself.…”
Section: Discussionsupporting
confidence: 91%
“…In our cohort, 24% of the critically ill medical patients were obese or morbidly obese, as defined by a BMI above 30 kg/m 2 . This is in line with observations in the United States, where at least 25% of adult ICU patients are overweight, obese, or morbidly obese [ 30 , 31 ]. Interestingly, we did not find dysregulated visfatin levels between ICU patients with or without obesity, supporting that circulating visfatin levels in critical illness are primarily attributable to the extent of inflammation and not adiposity itself.…”
Section: Discussionsupporting
confidence: 91%
“…As discussed before, although obesity is shown to be associated with poor outcomes in trauma patients (19), it may be protective in critically ill patients with sepsis (27, 62). However, more studies are needed to confirm these observations.…”
Section: Obesity and Animal Models Of Critical Illnessmentioning
confidence: 94%
“…An interesting trend in the literature is that obesity has recently been shown to be associated with poor outcomes in certain subsets of critically ill patients, such as those with severe trauma (19), while also appearing to be protective in other patients such as those with sepsis (the “obesity paradox”) (27, 62). These disparate findings are most likely due to artifacts of data collection or differences in pre-existing conditions, medical treatments, and inconsistent classifications of obesity and critical illness.…”
Section: Obesity and Animal Models Of Critical Illnessmentioning
confidence: 99%
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“…In addition, obese individuals have higher risk of developing several chronic diseases leading to end-stage organ failure as well as higher risk of cancer and infections [6,9]. All of the above conditions may lead to acute complications and hospitalizations, and it is therefore all but surprising that obese patients are increasingly common in intensive care units (ICUs), where according to recent epidemiological data up to one-third of admissions may indeed involve obese individuals [19,20]. Most importantly, chronic and acute diseases have a general negative impact on nutritional state, and disease-related malnutrition is recognized as a relevant cause of undernutrition in all clinical settings [21], largely through its negative impact on skeletal muscle protein-anabolic pathways and function that may be combined with variable degrees of anorexia and reduced volitional food intake [22][23][24].…”
Section: Obesity and Disease-related Malnutritionmentioning
confidence: 99%