The Occurrence of Anemia in Four Generations

A Family Study of Pernicious Anaemia

“…Since Sinkler and Eshner (1896) first reported the existence of pernicious anaemia and hypochromic anaemia in a single family, several similar families have been described (Maclachlan and Kline, 1926;Witts, 1930;Hcath, 1933;Lundholm, 1938;Kaufmann and Thiessen, 1939). In some the male members have had pernicious anaemia, the females hypochromic anaemia, and this has led to the suggestion that hypochromic anaemia may be another feature Family Study of Pernicious Anaemia 101 of the pernicious-anaemia constitution (Wintrobe and Beebe, 193 3 ;Askey, 1940;Neel, 1947).…”

The stomach in iron-deficiency anaemia.

“…Such difficulties in classification make family studies important and these tend to associate pernicious anaemia with idiopathic iron-deficiency anaemia. (MacLachlan and Kline, 1926;Heath, 1933;McFadyen, Goldberg, Dagg, and Anderson, 1967;Wangel, Callender, Spray, and Wright, 1968). It should be noted that iron is less well absorbed in achlorhydria (Goldberg, Lochhead, and Dagg, 1963) as is reflected in the iron deficiency that can accompany pernicious anaemia (Gibson, Kelly, and Wang, 1963).…”