The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview

Calabrese, Edward J.; Blain, Robyn

doi:10.1016/j.taap.2004.06.023

Cited by 489 publications

(304 citation statements)

References 3 publications

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“…Calabrese and co-workers found more than 5000 hormetic dose-response relationships published for over 900 chemical and physical agents. (Calabrese and Blain 2005) Given the vast array of chemical and physical agents and their different mechanisms of action, hormetic effects are unlikely to be the result of a single molecular mechanism and more likely to be related to a disruption of homeostasis (Hayes 2007). It may be helpful to view the effects of antioxidants generally and the neuroprotective effects of STAZN in particular in this context.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: Dose–response and therapeutic window

et al. 2007

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Stilbazulenyl nitrone (STAZN) is a potent antioxidant that, in a rat model of transient focal cerebral ischemia, confers significant enduring functional and morphological neuroprotection. This study investigated the influence of dose and time of administration on the neuroprotective effects of STAZN in the intraluminal-suture model of middle cerebral artery occlusion (MCAo).Dose-Response-At 2 and 4h after the onset of MCAo, animals received intravenously either STAZN (low dose=0.07 mg/kg, n=8), (medium dose=0.7 mg/kg, n=9), (high dose=3.5 mg/kg, n=9), an equivalent volume of vehicle (30% Solutol HS15 and 70% isotonic saline, 0.37 ml/kg, n=5), or saline (0.37 ml/kg, n=5). Only the medium dose improved scores (p<0.05) on a standardized neurobehavioral test at 1, 2 and 3d after MCAo. Only the medium dose reduced the total infarction (51%, p=0.014) compared to controls. These results indicate that STAZN exhibits maximal neuroprotection at the 0.7 mg/kg dose.Therapeutic Window-STAZN (0.6 mg/kg) dissolved in dimethylsulfoxide was given intraperitoneally at 2 and 4h (n=11), 3 and 5h (n=10), 4 and 6h (n=10), or 5 and 7h (n=7) after the onset of MCAo. Additional doses were given at 24 and 48h. Vehicle (dimethylsulfoxide, 2.0 ml/kg, n=6) was administered at 3, 5, 24 and 48h. STAZN treatment initiated at 2 or 3h after the onset of MCAo improved neurological scores (p<0.001) and reduced total infarction (42.2%, p<0.05) compared to controls.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: Dose–response and therapeutic window

et al. 2007

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“…This is termed hormesis (Phillip et al, 2000). Hormesis aroused more and more interests of researchers but the mechanism is not well understood (Calabrese, 2005;Stebbing, 1998;Calabrese and Blain, 2005). This paper offered a calorimetric method for studied the hormesis.…”

Section: Discussionmentioning

confidence: 99%

Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth

Zheng

Liu

Zhang

et al. 2006

Environmental Toxicology and Pharmacology

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“…For example, the effects of antioxidants as well as caloric restriction on the behavior of mortality curves in mice and rats do not indicate that these treatments alter the rates of aging [13] . Remarkably, many authors now recognize the life-extending and anti-aging actions of caloric restriction (most compelling example of life span extension by external manipulation) as an example of hormesis [14][15][16] (though other authors do not share this view [10] ).…”

Section: Life Extension Patterns By Anti-aging Drugs and By Hormetic mentioning

confidence: 99%

“…Chemical hormesis was observed in a wide range of taxonomic groups and involved agents representing highly diverse chemical classes [9] . In experimental studies, chemical hormesis was repeatedly exhibited by feeding of antibiotics, herbicides, pesticides, insecticides, hydrocarbons, ethanol, solvents and several other classes of chemicals in various organisms, including plants, viruses, bacteria, fungi, insects, fish, birds, rodents and primates [10] . For gerontologists, most important are the survivalenhancing aspects of hormesis.…”

Section: Introductionmentioning

confidence: 99%

Life Extension by Anti-Aging Drugs: Hormetic Explanation?

Vaiserman¹

2008

American J. of Pharmacology and Toxicology

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A number of chemicals including antioxidants, vitamins and hormones are widely advertised as anti-aging drugs (geroprotectors). It is usually believed that life-extending capacity of geroprotectors may be attributed to their specific anti-aging mechanisms, even without solid scientific evidence. The analysis of the survival data gathered by both anti-aging and hormetic interventions demonstrates that many essential similarities exist between them. The evidence that life-extending effects of anti-aging drugs may be due to hormetic-like response is discussed in this review.

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The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview

Cited by 489 publications

References 3 publications

Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: Dose–response and therapeutic window

Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: Dose–response and therapeutic window

Microcalorimetric investigation of the toxic action of Cr(VI) on the metabolism of Tetrahymena thermophila BF5 during growth

Life Extension by Anti-Aging Drugs: Hormetic Explanation?

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