The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults

Young, Terry; Palta, Mari; Dempsey, Jerome A.; Skatrud, James B.; Weber, Stephanie; Badr, Safwan

doi:10.1056/nejm199304293281704

Cited by 9,116 publications

(6,023 citation statements)

References 26 publications

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“…In patients with late onset disease, this may occur while the upright vital capacity is only moderately abnormal due to the disproportionate diaphragmatic involvement 47. Pompe patients may also have an impaired ability to compensate for any obstructive sleep apnea that may be present51–53 leading to worsened hypercapnia and hypoxemia 41,54. Progression to cor pulmonale and cardiorespiratory failure is possible.…”

Section: Pulmonarymentioning

confidence: 99%

Pompe disease diagnosis and management guideline

Kishnani

Steiner

Bali

et al. 2006

Genetics in Medicine

503

583

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Section: Pulmonarymentioning

confidence: 99%

Pompe disease diagnosis and management guideline

Kishnani

Steiner

Bali

et al. 2006

Genetics in Medicine

503

583

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“…In the developed world, between 5% and 10% of the adult population suffer from asthma 3. Depending on the criteria used for diagnosis, OSAS affects 2‐4% of men and 1‐2% of women in the United States 4, with an estimated prevalence of 3‐6% in the general Spanish population 5. Being so prevalent, it is inevitable that a significant percentage of patients suffer from both diseases simultaneously.…”

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confidence: 99%

Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea

Serrano-Pariente

Plaza

Soriano

et al. 2016

Allergy

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BackgroundContinuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies.MethodsProspective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index ≥20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention‐to‐treat basis.ResultsThe mean ± SD score of the ACQ decreased from 1.39 ± 0.91 at baseline to 1.0 ± 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 ± 1.38 to 5.63 ± 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients’ weight.ConclusionsAsthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.

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“…The severity of the disease can be screened for using two indices: The Apnoe–Hypopnoe Index (AHI) and Oxygen Desaturation Index (ODI). The AHI represents the number of apnoeas and hypopnoeas per hour of sleep; an AHI <5 per hour is considered physiological 45. An AHI 5–15 per hour defines a mild, AHI 15–30 per hour a moderate, and AHI >30 per hour a severe form of sleep‐disordered breathing.…”

Section: Clinical Presentationmentioning

confidence: 99%

Sleep‐disordered breathing in heart failure: facts and numbers

Pietrock

Haehling

2017

ESC Heart Failure

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Sleep‐disordered breathing has a high prevalence in the general population, but is especially prominent in patients with heart failure (HF). HF and sleep‐disordered breathing share a bidirectional relationship, with sleep‐disordered breathing being both cause and effect of poor cardiac functioning. The high inter‐individual variability of symptom presentation can impede the clinical diagnostic process. Polysomnography is the gold‐standard method of diagnosing sleep‐disordered breathing. Therapy of sleep‐disordered breathing should always consist of optimizing the treatment of the underlying disorder of HF. Additional therapeutic measures include continuous positive airway pressure ventilation therapy. New therapeutic options using neurostimulation are yielding promising results; however, long‐term benefits still need to be confirmed.

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The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults

Abstract: The prevalence of undiagnosed sleep-disordered breathing is high among men and is much higher than previously suspected among women. Undiagnosed sleep-disordered breathing is associated with daytime hypersomnolence.

Cited by 9,116 publications

References 26 publications

Pompe disease diagnosis and management guideline

Pompe disease diagnosis and management guideline

Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea

Sleep‐disordered breathing in heart failure: facts and numbers

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