The old worldsalsolaas a source of valuable secondary metabolites endowed with diverse pharmacological activities: a review

Abstract

Salsola is an important genus in the plant kingdom with diverse traditional, industrial, and environmental applications. Salsola species are widely distributed in temperate regions and represent about 45% of desert plants. They are a rich source of diverse phytochemical classes, such as alkaloids, cardenolides, triterpenoids, coumarins, flavonoids, isoflavonoids, and phenolic acids. Salsola spp. were traditionally used as antihypertensive, anti-inflammatory, and immunostimulants. They attracted great interest from researchers as several pharmacological activities were reported, including analgesic, antipyretic, antioxidant, cytotoxic, hepatoprotective, contraceptive, antidiabetic, neuroprotective, and antimicrobial activities. Genus Salsola is one of the most notorious plant genera from the taxonomical point of view. Our study represents a comprehensive review of the previous phytochemical and biological research on the old world Salsola secies. It is designed to be a guide for future research on different plant species that still belong to this genus or have been transferred to other genera.

New analysis of the endemic vascular plants of Algeria, their diversity, distribution pattern and conservation status

“…Widely distributed in arid and semi-arid regions of the world (ElNaggar & al. 2022), the genus Salsola is represented in Algeria by 11 species and varieties (Quézel & Santa 1962–1963) to 22 species and subspecies (Dobignard & Chatelain 2010–2013).…”

Investigation of bioactive components responsible for the antibacterial and anti-biofilm activities ofCaroxylon volkensiiby LC-QTOF-MS/MS analysis and molecular docking

“…This group is represented by moupinamide (Ntrans-feruloyltyramine, 1.22), which was reported in several Salsola species. 15,44 Other derivatives such as cinnamoyl (1.19), S1 † and Fig. 2).…”

“…19 Various plant species within the Old-World Salsola genus have been documented for their ability to exhibit antimicrobial effects against diverse pathogens. 15 Hence, in the present research, we investigated the antibacterial properties of C. volkensii and claried its capabilities in inhibiting biolm formation and disrupting quorum sensing in clinical isolates of Pseudomonas aeruginosa.…”

Recent advances on the regulation of bacterial biofilm formation by herbal medicines

“…Moreover, diallyl disulfide had beneficial effects on establishment of microbiota biofilms and colonic mucus production that alleviate murine colitis ( Motta et al, 2015 ). Coumarins are a class of organic compounds which are not only isolated from sieve bean, but also in many different plants, such as Tonka beans, verbena, wild vanilla and orchid ( ElNaggar et al, 2022 ). Studies found that some coumarins including esculetin and furocoumarins have broad range anti-biofilm activity by disturbing QS in S. aureus , E. coli , S. typhimurium , and P. aeruginosa via reduction of AHL ( Girennavar et al, 2008 ; Dürig et al, 2010 ).…”

“…Coumarin is found in tonka beans, verbena, wild vanilla and orchid, and has the smell of fresh hay and fenugreek ( ElNaggar et al, 2022 ). Coumarins have been shown to have antibacterial activity as a QSI in a broad spectrum of pathogens.…”