The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again

Abstract

It is generally accepted that carcinogenesis and aging are two biological processes, which are known to be associated. Notably, the frequency of certain cancers (including lung cancer), increases significantly with the age of patients and there is now a wealth of data showing that multiple mechanisms leading to malignant transformation and to aging are interconnected, defining the so-called common biology of aging and cancer. OncoAge, a consortium launched in 2015, brings together the multidisciplinary expertise of leading public hospital services and academic laboratories to foster the transfer of scientific knowledge rapidly acquired in the fields of cancer biology and aging into innovative medical practice and silver economy development. This is achieved through the development of shared technical platforms (for research on genome stability, (epi)genetics, biobanking, immunology, metabolism, and artificial intelligence), clinical research projects, clinical trials, and education. OncoAge focuses mainly on two pilot pathologies, which benefit from the expertise of several members, namely lung and head and neck cancers. This review outlines the broad strategic directions and key advances of OncoAge and summarizes some of the issues faced by this consortium, as well as the short- and long-term perspectives.

Investigación sobre la producción científica en relación con la silver economy

“…Respecto a cuestiones relacionadas con la salud, hay estudios para aplicar innovaciones, como el enfoque centrado en la persona, con el objetivo de mejorar los resultados sanitarios, la calidad de vida y la sostenibilidad de los servicios sociales y sanitarios (De Luca et al, 2021). Del mismo modo, se alude a la tecnología digital para aumentar la eficacia de los servicios sanitarios (Erceg et al, 2021;Hofman et al, 2019); o a la importancia de mejorar la calidad, en términos de diseño de los productos sanitarios (Guo et al, 2018). En general, existe una amplia preocupación por la mejora de la calidad de vida de las personas mayores (Hvozdikova et al, 2015;Kavšek et al, 2021), como en los estudios que advierten del riesgo de desnutrición en ancianos y la oportunidad para la industria de la alimentación de desarrollar alimentos con alto contenido en nutrientes y precio asequible (Duta et al, 2011) pero, a pesar de las diferentes innovaciones, hay dificultades para que estas lleguen al mercado (Lettieri et al, 2022).…”

Eco‐evolutionary perspectives of the dynamic relationships linking senescence and cancer

“…As the immediate results of the proximal deteriorations occurring with age, both processes of carcinogenesis and senescence should be tightly linked. However, understanding the causality of the relationship linking cancer and senescence (at cellular, individual and population levels) and deciphering their complexity through the lenses of evolutionary biology is particularly arduous (Hofman et al, 2019). In that context, several hypotheses have recently emerged.…”