The Onset of Diabetes During Transcranial Direct Current Stimulation Treatment of Anorexia Nervosa — A Case Report

Mareš, Tadeáš; Čerešňáková, Silvie; Albrecht, Jakub; Buday, Jozef; Klasova, Johana; Horackova, Klara; Raboch, Jiří; Papežová, Hana; Anders, Martin

doi:10.3389/fpsyt.2020.00040

Cited by 5 publications

(7 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This gain in performance was associated with an unaltered blood glucose response in the two conditions, extending the benefits of this methodology also to a specific population. This ultimate finding was partially unexpected, considering the controversial results of few studies analyzing the effects of tDCS on glycemic response [17,32]. It is plausible that negative result of previous studies could be due to the lower focality of the traditional tDCS.…”

Section: Discussionmentioning

confidence: 93%

Effects of bilateral dorsolateral prefrontal cortex high-definition transcranial direct-current stimulation on time-trial performance in cyclists with type 1 diabetes mellitus

Filipas¹,

Gallo²,

Meloni³

et al. 2022

Brain Stimulation

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 93%

Effects of bilateral dorsolateral prefrontal cortex high-definition transcranial direct-current stimulation on time-trial performance in cyclists with type 1 diabetes mellitus

Filipas¹,

Gallo²,

Meloni³

et al. 2022

Brain Stimulation

View full text Add to dashboard Cite

“…Interestingly, one of the patients indicated an improvement of toothache; one mentioned remission of headache; and another patient noticed a decline in night sweating. On the contrary, there was an onset of type I diabetes mellitus in one patient with active tDCS (32).…”

Section: Resultsmentioning

confidence: 84%

“…Two females (sham group) requested to leave the study without disclosing the reason. Side effects represented the last reason (all four patients were from the active group): two patients left due to headache, another one was excluded following mood changes (toward hypomania), and one patient had troubles with blood sugar and an onset of diabetes (32). As a result, the data of 17 patients in the stimulated group and 16 in the sham (placebo) group remained eligible for the statistical analysis at the time of stage 2.…”

Section: Participantsmentioning

confidence: 99%

Effects of Transcranial Direct Current Stimulation Treatment for Anorexia Nervosa

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background: Anorexia nervosa (AN) is a life-threatening illness with poor treatment outcomes. Although transcranial direct current stimulation (tDCS) is a promising non-invasive brain stimulation method, its effect in patients with AN remains unclear.Objective: This study investigated changes in maladaptive eating behavior, body mass index (BMI), and depression after 10 sessions of anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC).Methods: In this double-blind, randomized controlled trial, 43 inpatients with AN were divided to receive either active (n = 22) or sham (n = 21) tDCS over the left DLPFC (anode F3/cathode Fp2, 2 mA for 30 min). All patients filled the Eating Disorder Examination Questionnaire (EDE-Q) and Zung Self-Rating Depression Scale (ZUNG), and their BMI was measured. These values were obtained repeatedly in four stages: (1) before tDCS treatment, (2) after tDCS treatment, (3) in the follow-up after 2 weeks, and (4) in the follow-up after 4 weeks.Results: Primary outcomes (EDE-Q) based on the ANOVA results do not show any between-group differences either after the active part of the study or in the follow-up. Secondary analysis reveals a reduction in some items of EDE-Q. Compared with sham tDCS, active tDCS significantly improved self-evaluation based on body shape (p < 0.05) and significantly decreased the need of excessive control over calorie intake (p < 0.05) in the 4-week follow-up. However, the results do not survive multiple comparison correction. In both sham and active groups, the BMI values improved, albeit not significantly.Conclusion: We did not observe a significant effect of tDCS over the left DLPFC on complex psychopathology and weight recovery in patients with AN. tDCS reduced the need to follow specific dietary rules and improved body image evaluation in patients with AN. Tests with a larger sample and different positions of electrodes are needed.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT03273205.

show abstract

“… Significant improvement in multiple eating disorder subscales, but not significant between groups. AN Phillipou, 2019 [ 67 ] Australia 20 Anodal stimulation for 20 min at 2 mA 10 sessions Anode over left inferior parietal lobe Currently underway AN Mares, 2020 [ 68 ] Czechia 1 30 min of 2 mA anodal stimulation 7 sessions Left dlPFC anode with cathode over the right orbitofrontal region 11 years 17.4 kg/m 2 N/A During tDCS, the patient developed hyperglycemia and, subsequently, diabetes mellitus. AN Ursumando, 2023 [ 69 ] Italy 80 20 min of 1 mA stimulation 1 session F3 (anode) and F4 (cathode) of dlPFC Currently underway BN Kekic, 2017 [ 46 ] UK 39 20 min of 2 mA with 10 s ramp on/off 3 sessions F4 (anode) and F3 (cathode) of dlPFC in one group; F3 (anode) and F4 (cathode) of dlPFC in the other group Mean 9.25 years Mean of 21.65 kg/m 2 N/A …”

Section: Current Neuromodulatory Options and Their Target Network/nodesmentioning

confidence: 99%

Neuromodulation of Eating Disorders: A Review of Underlying Neural Network Activity and Neuromodulatory Treatments

Wu,

Lo,

Cavaleri

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

Eating disorders are a group of psychiatric conditions that involve pathological relationships between patients and food. The most prolific of these disorders are anorexia nervosa, bulimia nervosa, and binge eating disorder. The current standard of care involves psychotherapy, pharmacotherapy, and the management of comorbid conditions, with nutritional rehabilitation reserved for severe cases of anorexia nervosa. Unfortunately, many patients often fail to respond, leaving a concerning treatment gap between the current and requisite treatments for eating disorders. To better understand the neurobiology underlying these eating disorders, investigations have been undertaken to characterize the activity of various neural networks, primarily those activated during tasks of executive inhibition, reward processing, and self-reference. Various neuromodulatory techniques have been proposed to stimulate these networks with the goal of improving patients’ BMI and mental health. The aim of this review is to compile a comprehensive summarization of the current literature regarding the underlying neural connectivity of anorexia nervosa, bulimia nervosa, and binge eating disorder as well as the numerous neuromodulatory modalities that have been investigated. Importantly, we aimed to summarize the most significant clinical trials to date as well as to provide an updated assessment of the role of deep brain stimulation, summarizing numerous recently published clinical studies that have greatly contributed to the literature. In this review, we found therapeutic evidence for transcranial magnetic stimulation and transcranial direct current stimulation in treating individuals suffering from anorexia nervosa, bulimia nervosa, and binge eating disorder. We also found significant evidence for the role of deep brain stimulation, particularly as an escalatory therapy option for the those who failed standard therapy. Finally, we hope to provide promising directions for future clinical investigations.

show abstract

The Onset of Diabetes During Transcranial Direct Current Stimulation Treatment of Anorexia Nervosa — A Case Report

Cited by 5 publications

References 30 publications

Effects of bilateral dorsolateral prefrontal cortex high-definition transcranial direct-current stimulation on time-trial performance in cyclists with type 1 diabetes mellitus

Effects of bilateral dorsolateral prefrontal cortex high-definition transcranial direct-current stimulation on time-trial performance in cyclists with type 1 diabetes mellitus

Effects of Transcranial Direct Current Stimulation Treatment for Anorexia Nervosa

Neuromodulation of Eating Disorders: A Review of Underlying Neural Network Activity and Neuromodulatory Treatments

Contact Info

Product

Resources

About