The Opportunities for developing a new biologically active suture material in surgery (literature review)

Морозов, А. М.; Михайлович, Морозов Артем; Mokhov, Evgeny Mikhailovich; Михайлович, Мохов Евгений; Lyubsky, Igor Vyacheslavovich; Вячеславович, Любский Игорь; Сергеев, А.Н.; Николаевич, Сергеев Алексей; Kadykov, V.A.; Аскеров, Э. М.; Магомедович, Аскеров Эльшад; Peltikhina, O.V.; Владиславовна, Пельтихина Ольга; Horák, K; Иосифович, Хорак Константин

doi:10.18499/2070-478x-2019-12-3-193-198

Cited by 9 publications

(1 citation statement)

References 2 publications

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“…In modern surgical dentistry, new suture materials are being developed and existing ones are being improved [ 7 ], alongside the improvement of methods for their application [ 8 ]. According to some authors, postoperative complications with unknown etiology may be the result of improper suturing technique, resulting in untying of knots and loss of flaps’ tension [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Mechanical Properties and Microbiological Resistance of Polyfilament and Monofilament Suture Materials Used in the Operation “Tooth Extraction”

et al. 2023

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In surgical dentistry, suture material is the only foreign body that remains in the tissues after surgery, and it can lead to several negative reactions, for example, infection of the wound. The purpose of this study was to compare the mechanical properties and microbiological resistance of mono- and polyfilament suture materials used in tooth extraction operations. The study of elongation and knot force was carried out on an Instron 5969 Dual Column Testing System device. The capillarity of the materials was studied on a setup assembled by the authors manually by immersing the ends of the filaments in a colored manganese solution. A microbiological study was carried out on the threads taken for the experiment immediately after wound suturing, and on day 7, at which time they were removed. The comparison was made according to Rothia mucilaginosa, Streptococcus sanguinis, Staphylococcus epidermidis. Results: monofilament suture materials (Prolene and Glycolon), after calculating the Kruskal–Wallis and Mann–Whitney indices, showed better performance in all experiments compared to polyfilament sutures (Vicryl and PGA). In capillarity comparison, there was a significant difference between groups (p = 0.00018). According to the sum of the results of three microbiological studies on day 7, monofilament suture materials absorbed less of the studied bacteria on their surface compared to the polyfilament ones (p < 0.05). Conclusions: Of the studied suture materials, Prolene had the best microbiological resistance and good mechanical properties.

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Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Mechanical Properties and Microbiological Resistance of Polyfilament and Monofilament Suture Materials Used in the Operation “Tooth Extraction”

et al. 2023

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Application of Suture Material Impregnated with Miramistin in Diffuse Peritonitis: Experimental-Clinical Justification

Sukovatykh,

Mosolova,

Zatolokina

et al. 2021

VECS

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Introduction. In diffuse peritonitis, the incidence of intestinal suture incompetence ranges from 5 to 15%, and suppuration of the surgical wound from 15% to 30%. The aim of research was to study experimentally the course of the wound process in the intestinal wall in diffuse peritonitis using suture material impregnated with miramistin, and to evaluate the effect of this material on the incidence of intestinal suture failure and suppuration of surgical wounds in a surgical practice. Materials and methods. The experimental study involved 192 male Wistar rats divided into 2 groups, 96 animals each; the clinical study involved 20 patients with traumatic intestinal tube wounds, who were also divided into 2 groups. Peritonitis was simulated by introducing 10% fecal suspension into the abdominal cavity. A laparotomy was performed in 24 hours, then the abdominal cavity was washed with sterile saline and a wound 1 cm long was performed in the colon wall. In animals of the first (control) group the wound was sutured with polyglycolide suture material without an antibacterial coating, in animals of the second (experimental) group the wound was sutured with polyglycolide suture material covered with polymer solution containing 20% Miramistin based on the polymer weight. In 10 patients of the first clinical group, intestinal wounds were sutured with similar suture materials without antibacterial coating, and the abdominal wall was sutured using interrupted stitches with lavsan suture materials. In 10 patients of the second group, wounds of the intestinal tube and the abdominal wall were sutured with suture materials impregnated with 20% Miramistin. Results. In animals of the first group, the pronounced phase of inflammation of the intestinal wall lasted 7 days, inflammation subsided and start of the proliferative phase was recorded in 14 days, restriction of the intestinal suture by the connective tissue elements was registered in 21 days of the experiment. In animals of the second group, the phase of inflammation lasted 3 days, the proliferative phase ended in 7 days, restriction of the intestinal suture by the new connective tissue with complete restoration of the architectonics of the intestinal wall was recorded in 14 days. In patients of the first clinical group, intestinal suture failure developed in 2 patients (20%), and surgical wound suppuration - in 4 patients (40%) with one lethal outcome. Inpatients of the second clinical group, intestinal suture failure, deaths and suppuration of surgical wounds were not registered. Conclusion. The use of suture material impregnated with polymer solution containing 20% miramistin by the polymer weight in peritonitis was pathogenetically justified to be effective.

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Historical aspects of aseptics and antiseptics

Морозов

Сергеев

Жуков

et al. 2021

vmirvz

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Relevance. For many centuries, infectious complications have been one of the most pressing problems of surgical practice. In modern medicine, a wide range of aseptic and antiseptic methods is presented, which, without harm to the body, can destroy pathogenic microorganisms and prevent the development of purulent complications that significantly aggravate the patient's condition and increase the duration of treatment. However, this was not always the case. In the era of the formation of surgery, interventions in a significant majority of cases ended with the development of purulent and septic complications, which inevitably led to death.The purpose of this study was to study the main points that play a key role in the history of the formation of modern asepsis and antiseptics.Material and methods. In the course of the study, an analysis of domestic and foreign literature on the history of the development of aseptics and antiseptics was carried out. When compiling the work, the biographical method of historical research was used. Articles and historical sketches of the period of the described events were also used as materials.Results. The formation of the principles of asepsis and antisepsis is a long historical process in which many of the greatest minds of mankind have been involved. At the same time, like the development of any scientific worldview, the development of asepsis and antiseptics was based on previous knowledge, as well as on knowledge obtained, mainly empirically. From time immemorial, physicians have already had an idea of the antibacterial properties of a number of compounds. The first mentions of attempts to prevent contamination of wounds and their disinfection date back to the time of Hippocrates. In the Middle Ages, for the purpose of disinfecting wounds, cauterization with a red-hot iron and boiling oil was widely used. From the middle of the 18th century, the first antiseptics entered the practice of surgeons. From the middle of the 19th century, a significant contribution to the development of asepsis and antiseptics was made by the Russian surgeon N.I. Pirogov, and his follower N.V. Sklifosovsky. A breakthrough in the development of asepsis and antiseptics in the late 19th – early 20th centuries was the scientific discovery of the French scientist Louis Pasteur, who proved that the processes of fermentation and decay are caused by microorganisms. This discovery formed the basis of J. Lister's antiseptic method. At the end of the 19th century, E. von Bergmann developed the aseptic method. One of the last significant events in the history of antiseptics was A. Fleming antibiotics.Conclusions. Thanks to the work of great scientists and doctors, there are many lifethreatening postoperative complications that claimed the lives of many people, if they did not remain in the past, then their incidence and intensity of manifestations have noticeably decreased, and asepsis and antiseptics have become an integral component of surgical practice.

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The Opportunities for developing a new biologically active suture material in surgery (literature review)

Cited by 9 publications

References 2 publications

Comparative Analysis of Mechanical Properties and Microbiological Resistance of Polyfilament and Monofilament Suture Materials Used in the Operation “Tooth Extraction”

Comparative Analysis of Mechanical Properties and Microbiological Resistance of Polyfilament and Monofilament Suture Materials Used in the Operation “Tooth Extraction”

Application of Suture Material Impregnated with Miramistin in Diffuse Peritonitis: Experimental-Clinical Justification

Historical aspects of aseptics and antiseptics

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