The optimal window time to treat noise-induced hearing loss (NIHL) with low level laser therapy (LLLT)

Chang, So Young; Suh, Myung‐Whan; Bahk, Chan Woong; Jung, Jae Yun; Ahn, Jin Ho; Chung, Phil‐Sang; Rhee, Choong Kyun

doi:10.1117/12.912431

Cited by 1 publication

(7 citation statements)

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“…Overall, there was a trend toward benefit from PBMT in animal studies, irrespective of delivery method, wavelength and power used or the animal species treated. Audiological outcomes improved in all 16 animal studies following PBMT compared to no PBMT, with statistically significant improvement stated in 11 studies 12,13,19,20,22–27,29 . In the single human study included, no statistically significant effect of PBMT on hearing was detected 7 .…”

Section: Resultsmentioning

confidence: 87%

“…Audiological outcomes improved in all 16 animal studies following PBMT compared to no PBMT, with statistically significant improvement stated in 11 studies. 12,13,19,20,[22][23][24][25][26][27]29 In the single human study included, no statistically significant effect of PBMT on hearing was detected. 7 Notably, the PBMT wavelength was shorter, and the power used lower compared to all animal studies.…”

Section: Photobiomodulation Therapy Outcomesmentioning

confidence: 88%

“…30 A range of otological insults were used to induce hearing losses in each animal study: noise induced hearing loss (NIHL) (n = 9), gentamicin-induced ototoxicity (n = 4), surgical trauma (n = 1), oubain-induced auditory neuropathy (n = 1) and pre-treatment for CI surgery induced hearing loss (n = 1). 12,13,[18][19][20][21][22][23][24][25][26][27][28][29][30][31] Direct comparison of differing ototoxic agents was not conducted in any of the studies included.…”

Section: Photobiomodulation Therapy Outcomesmentioning

confidence: 99%

“…Seventeen studies met the inclusion criteria with a total of 397 subjects (30 humans in a single study, 327 animals in 11 studies, and 40 animal specimens in 5 laboratory studies). 7,12,13,[18][19][20][21][22][23][24][25][26][27][28][29][30][31] Only one study, a randomised controlled trial, assessed the effect of PBMT on humans. Subjects were selected for inclusion using an unspecified screening questionnaire and randomly allocated to a control, treatment and placebo group.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…ABR taken before, immediately after, and at common. 13,[19][20][21][22][23][24][25]27,28,30,31 All studies, except two, outlined where PBMT was anatomically focussed. 12,25…”

Section: Audiological Datamentioning

confidence: 99%

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The effect of photobiomodulation on hearing loss: A systematic review

Nikookam,

Zia,

Lotfallah

et al. 2023

Clinical Otolaryngology

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ObjectivesTo assess outcomes associated with photobiomodulation therapy (PBMT) for hearing loss in human and animal studies.DesignSystematic review and narrative synthesis in accordance with PRISMA guidelines.SettingData bases searched: MEDLINE, EMBASE, CENTRAL, ClinicalTrials.gov and Web of Science. No limits were placed on language or year of publication. Review conducted in accordance with the PRISMA 2020 statement.ParticipantsAll human and animal subjects treated with PBMT for hearing loss.Main outcome measuresPre‐ and post‐PBMT audio metric outcomes.ResultsSearches identified 122 abstracts and 49 full text articles. Of these, 17 studies met the inclusion criteria, reporting outcomes in 327 animals (11 studies), 30 humans (1 study), and 40 animal specimens (5 studies). PBMT parameters included 6 different wavelengths: 908 nm (1 study), 810 nm (1 study), 532 & 635 nm (1 study), 830 nm (3 studies), 808 nm (11 studies). The duration ranged from 4 to 60 minutes in a session, and the follow‐up ranged from 5–28 days. Outcomes improved significantly when wavelengths within the range of 800–830 nm were used, and with greater duration of PBMT exposure. Included studies predominantly consisted of non‐randomized controlled trials (10 studies).ConclusionsHearing outcomes following PBMT appear to be superior to no PBMT for subjects with hearing loss, although higher level evidence is required to verify this. PBMT enables concentrated, focused delivery of light therapy to the inner ear through a non‐invasive manner with minimal side effects. As a result of heterogeneity in reporting PBMT parameters and outcomes across the included studies, direct comparison is challenging.

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Section: Resultsmentioning

confidence: 87%

Section: Photobiomodulation Therapy Outcomesmentioning

confidence: 88%

Section: Photobiomodulation Therapy Outcomesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

“…ABR taken before, immediately after, and at common. 13,[19][20][21][22][23][24][25]27,28,30,31 All studies, except two, outlined where PBMT was anatomically focussed. 12,25…”

Section: Audiological Datamentioning

confidence: 99%

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