The oral health status of patients with peripheral vascular disorders: A systematic review

Abstract

Objectives Periodontal disease and tooth loss were found to be associated with several peripheral vascular disorders. Nonetheless, an evaluation of the literature on the broader domains of oral health in individuals with peripheral vascular disorders is lacking. This systematic review aims to collate the current evidence on the oral health status of individuals with peripheral vascular disorders. Methods Five electronic databases were searched for studies assessing oral health parameters in individuals with peripheral vascular disorders. Outcome measures considered were periodontal health, dentition status, caries indices, oral prostheses, oral pathologies and oral hygiene behaviours. The Newcastle-Ottawa scale was used to appraise the quality of the studies. Results From 3025 records identified, 24 studies involving 1232 participants with peripheral vascular disorders were included in this review. In nine studies, periodontitis was significantly more prevalent in peripheral vascular disorders compared to non-peripheral vascular disorders participants. A further six studies reported individuals with peripheral vascular disorders also had significantly fewer teeth and increased rates of edentulism. Only one study reported a higher incidence of dental caries in peripheral vascular disorders participants. Other aspects of oral health such as oral prosthesis, oral pathology and oral hygiene behaviours were seldom assessed. Conclusions The scarcity of studies reporting on broader domains limited our ability to arrive at a conclusion regarding the oral health status of individuals with peripheral vascular disorders. Future studies ought to assess these domains in individuals with peripheral vascular disorders and controls to gain a more complete understanding of oral health and its potential association with peripheral vascular disorders.

O tratamento periodontal e a prevenção de doenças cardiovasculares: revisão integrativa da literatura

“…Nos últimos anos, estudos destacam a possibilidade de inflamações locais comunicarem-se com outros órgãos do corpo humano favorecendo a disseminação de patógenos através de vias sistêmicas. Dessa forma, a ativação de mediadores inflamatórios, como interleucinas 1beta e 6 (IL-1β e IL-6), interferon-gamma (IFN-γ), matriz de metaloproteinase-9 (MMP-9), fator de necrose tumoral alfa (TNF-α), proteína C-reativa e prostaglandinas (PGE2), em processos de inflamação dos tecidos periodontais, poderia propiciar alterações em células endoteliais, distúrbios vasculares e/ou maior número de anticorpos contra microorganismos periodontopatogênicos em níveis sanguíneos, contribuindo para quadros de doenças cardiovasculares (DCVs) (Aoyama et al, 2019;Bergandi et al, 2019;Isola et al, 2020;Almoosawy et al, 2021;Samulak et al, 2021).…”