The Oral Microbiome of Healthy Japanese People at the Age of 90

Nomura, Yasuo; Kakuta, Erika; Kaneko, Noboru; Nohno, Kaname; Yoshihara, Akihiro; Hanada, Nobuhiro

doi:10.3390/app10186450

Cited by 5 publications

(3 citation statements)

References 79 publications

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“…In the study of healthy children, Proteobacteria was abundant in the group without dental caries, and Firmicutes and Bacteroides were abundant in the group with dental caries [21]. A study of healthy elderly people found that Firmicutes and Veillonella were abundant at the phyla level [22,23]. This was markedly different from the BS group in this study, in which Neisseria, Porphyromonas and Streptococcus were significant.…”

Section: Discussioncontrasting

confidence: 62%

The Oral Microbiome in Children with Black Stained Tooth

et al. 2020

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Black stain (BS) is a characteristic extrinsic discoloration, which occurs along the third cervical line of the buccal and/or lingual surfaces of teeth, particularly in the primary dentition of humans. BS is produced by oral bacteria and byproducts of saliva, but there is a controversy about related bacteria. The aim of this study was to identify the oral microbiome in tooth BS using pyrosequencing. It was hypothesized that the oral microbiome of BS in children might be related to black-pigment producing bacteria. Supragingival dental plaque was obtained from six children (mean 8.1 years) with BS and four children (mean 8.3 years) without BS. The bacterial metagenome was obtained by pyrosequencing. The BS group contained 348 operative taxonomic units (OTUs), whereas the control group had 293 OTUs. Microbial abundance and diversity were significantly higher in the BS group (p < 0.05). In the heatmap, the correlation between samples was the same as the BS scale. At the genus level, six genera—Abiotrophia, Eikenella, Granulicatella, Neisseria, Porphyromonas and Streptococcus—were significantly different between the two groups (p < 0.05). We suggested that compositional changes in the oral microbiome are essential, and several species in the genus Neisseria, Porphyromonas and Streptococcus may be major contributors for BS formation. Although the number of subjects was relatively limited, our study is the first species-level analysis of pyrosequencing data in BS formation.

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Section: Discussioncontrasting

confidence: 62%

The Oral Microbiome in Children with Black Stained Tooth

et al. 2020

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“…Microbiome analysis was conducted by Bioconductor on free software R ver 4.03. The package used in this study were microbiome, phyloseq, vegan, ape, knitr and Rtsne [19,20].…”

Section: Discussionmentioning

confidence: 99%

Incidence of Postoperative Pneumonia and Oral Microbiome for Patients with Cancer Operation

et al. 2022

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Postoperative pneumonia is a serious problem for patients and medical staff. In Japan, many hospitals introduced perioperative oral care management for the efficient use of medical resources. However, a high percentage of postoperative pneumonia still developed. Therefore, there is a need to identify the specific respiratory pathogens to predict the incidence of pneumonia The purpose of this study was to find out the candidate of bacterial species for the postoperative pneumonia. This study applied case-control study design for the patients who had a cancer operation with or without postoperative pneumonia. A total of 10 patients undergoing a cancer operation under general anesthesia participated in this study. The day before a cancer operation, preoperative oral care management was applied. Using the next generation sequence, oral microbiome of these patients was analyzed at the time of their first visit, the day before and after a cancer operation. Porphyromonas gingivalis and Fusobacterium nucleatum group can be a high risk at first visit. Atopobium parvulum and Enterococcus faecalis before a cancer operation can be a high risk. Poor oral hygiene increased the risk of incidence of postoperative pneumonia. Increased periodontal pathogens can be a high risk of the incidence of postoperative pneumonia. In addition, increased intestinal bacteria after oral care management can also be a high risk for the incidence of postoperative pneumonia.

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“…However, some pathogenic species are predominant in healthy subjects. For example, predominant bacteria such as the S. sinensis group and S. pneumoniae group are known to be the pathogens for pneumonia [6,7].…”

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confidence: 99%

Future Prospective of Oral Microbiome Research

2021

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Oral microbiome has complex structure. It consisted of more than 700 species of bacteria. These bacteria contains pathogens for human health. In contrast, some beneficial bacteria were included. Perspective of oral microbiome is not still elucidated. In this paper, information regarding oral microbiome of health older adults and oral diseases are included. Additionally, concise review of oral microbiome are presented.

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The Oral Microbiome of Healthy Japanese People at the Age of 90

Cited by 5 publications

References 79 publications

The Oral Microbiome in Children with Black Stained Tooth

The Oral Microbiome in Children with Black Stained Tooth

Incidence of Postoperative Pneumonia and Oral Microbiome for Patients with Cancer Operation

Future Prospective of Oral Microbiome Research

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