The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a blockcopolymer - poloxamine 908

Lymph node localisation of biodegradable nanospheres surface modified with poloxamer and poloxamine block co‐polymers

“…Free III In-oxine 14.1 ± 3.1 1.0 ± 0. cell-nanosphere interaction [21] should escape recognition by the lymph node macrophages and enter the general circulation. All coated systems exhibited an enhanced lymph node uptake compared to naked uncoated nanospheres.…”

Magnetically responsive microparticles for targeted drug and radionuclide delivery.

“…However, in-vivo results do not show such simple hydrophobic/hydrophilic patterns. Biodistribution of IV-injected particles indicates that relatively hydrophilic particles (e.g., proteins) are captured by the RES qualitatively to the same extent as are strongly hydrophobic particles such as polystyrene (Illum et al 1986(Illum et al , 1987. This means that, although hydrophobic interactions may play a part in the capture of foreign particles by the RES, other parameters are also involved.…”

Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers

“…These types of stabilized nanoparticles have long been known to evade uptake by the mononuclear phagocyte system (MPS), [28] and so for practical drug delivery purposes there is a strong rationale to develop polyesters which are easy to synthesise from renewable resources, and which can be easily formulated into drug-loaded nanoparticles.…”